PMID: 7031727Oct 1, 1981Paper

Effects of PGI2 on pattern of breathing in the pig during aortic obstruction

Prostaglandins and Medicine
M G ClementG Aguggini

Abstract

We studied the effects of prostacyclin on pattern in six anaesthetized pigs with aortic obstruction. PGI2 causes a rightward displacement of VT/TI relationship (Hering-Breuer threshold curve) without a corresponding change in inspiratory flow. With airways occluded at the end respiratory level, we analyze how PGI2 affects the central respiratory rhythm in the absence of the phasic lung volume-related vagal loop. Infusion of prostacyclin causes leftward displacement of the TE/TI relationship and an increase in TTOTo correlated with the hypotensive action. The change in the bulbo-pontine pacemaker is caused by a marked increase in TEo and this suggests that PGI2 can modulate the central respiratory rhythm, independently of the blood pressure level.

References

Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·R J GryglewskiJ Swies
Jul 1, 1981·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·M G ClementG Miserocchi
Jul 28, 1954·The Journal of Physiology·M DE BURGH DALYA SCHWEITZER
Feb 21, 1951·Acta Physiologica Scandinavica·E NEIL

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Citations

Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·M O TriulziG Aguggini

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