Abstract
1. The receptors mediating the vasodilator responses to adenosine in the isolated mesenteric arterial bed of the rat were identified by use of selective agonists and antagonists and the involvement of the endothelium was examined. 2. Adenosine-mediated dilatation of the mesentery was potentiated by the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME, 100 microM), but in contrast, removal of the endothelium substantially reduced the responses to adenosine. 3. The order of potency of adenosine receptor agonists was: 5'-N-ethylcarboxamidoadenosine (NECA) > 2-p-(-2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) > 2-chloro-N6-cyclopentyl-adenosine (CCPA) > or = adenosine, suggesting the presence of A2A receptors. 4. Adenosine-mediated dilatation was inhibited by the non-selective adenosine receptor antagonist, 8-phenyltheophylline (3 microM) and by the A2A receptor antagonist 8-(3-chlorostyryl)caffeine (500 nM), but was unaffected by the A1 receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX; 10 nM). 5. Reducing the pH of the perfusate to 6.8 potentiated the actions of both CGS 21680 and adenosine, but the vasodilator effects of carbachol were the same at both pH values. T...Continue Reading
References
Feb 1, 1978·Circulation Research·G F MerrillJ M Dabney
Feb 1, 1992·British Journal of Pharmacology·P VuorinenK E Laustiola
Jun 5, 1992·European Journal of Pharmacology·P L Martin
Dec 1, 1991·Circulation Research·V Ralevic, G Burnstock
Jun 1, 1991·British Journal of Pharmacology·S A DouglasC R Hiley
Sep 13, 1989·European Journal of Pharmacology·M F Jarvis, M Williams
Oct 1, 1989·British Journal of Pharmacology·M D RandallC R Hiley
Jun 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·M J LohseM Grifantini
Jun 1, 1995·British Journal of Pharmacology·A RubinoG Burnstock
Jan 1, 1995·Trends in Pharmacological Sciences·C J GarlandT M Cocks
Feb 1, 1995·Journal of Cardiovascular Pharmacology·H A OlanrewajuS J Mustafa
Sep 15, 1994·European Journal of Pharmacology·J O Schiele, U Schwabe
Feb 1, 1995·Circulation Research·B T Liang, B Haltiwanger
Oct 1, 1994·Journal of Neurochemistry·R Askalan, P J Richardson
Jan 1, 1994·British Journal of Pharmacology·S P AlexanderS J Hill
May 1, 1994·British Journal of Pharmacology·P VuorinenI Pörsti
Jun 1, 1993·British Journal of Pharmacology·A Vials, G Burnstock
Apr 1, 1993·Journal of Neurochemistry·G AllendeE I Canela
May 24, 1993·FEBS Letters·K A JacobsonJ W Daly
Mar 1, 1965·The Journal of Physiology·D D MCGREGOR
Citations
Apr 30, 2008·Purinergic Signalling·Manuela MoratoAntónio Albino-Teixeira
Jan 30, 2004·Vascular Pharmacology·Worku Abebe, Mahmood S Mozaffari
Sep 30, 2000·European Journal of Pharmacology·V Ralevic
Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Dec 1, 2001·Pharmacology & Therapeutics·R Tabrizchi, S Bedi
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·V RalevicD Smart
Oct 6, 1997·British Journal of Pharmacology·I QuéréM M Loubatières-Mariani
Jan 8, 1998·British Journal of Pharmacology·D J PrenticeS M Hourani
Oct 6, 2001·British Journal of Pharmacology·B M StavrouN A Flores
Mar 6, 2002·British Journal of Pharmacology·M T Villa de BritoM C Marques
Mar 27, 2003·Autonomic & Autacoid Pharmacology·J NichollsJ M Hall
Jan 5, 2013·Journal of Cardiovascular Pharmacology·Bunyen TengS Jamal Mustafa
Oct 29, 2003·British Journal of Pharmacology·Scott S WildmanBrian F King
Jun 24, 2008·Microscopy Research and Technique·Sandra LealCarmen Diniz
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuyoshi KataokaHiromichi Tsuru
Feb 12, 2013·European Journal of Pharmacology·Hanan M El-GowelliMahmoud M El-Mas
Dec 20, 2017·Frontiers in Pharmacology·Allan K N AlencarGisele Zapata-Sudo
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Apr 13, 2001·Journal of Cardiovascular Pharmacology·A VuylstekeC R Hiley
Mar 13, 2014·The International Journal of Artificial Organs·Ahmed NassarCristiano Quintini
Mar 13, 2015·Molecular Pharmacology·Guillaume LebonChristopher G Tate
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Edwin K JacksonStevan P Tofovic
Jun 14, 2018·Frontiers in Pharmacology·M Verónica DonosoJ Pablo Huidobro-Toro
Dec 11, 2020·Journal of Immunology Research·Fernanda Dos AnjosMargarete Dulce Bagatini
Mar 11, 2018·European Journal of Pharmacology·Ipsita MohantySatish Rattan