PMID: 3609975May 1, 1987Paper

Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T FujiiK Hiraga

Abstract

The effects of an alkalizer or an acidifier on bladder carcinogenesis induced by OPP or OPP-Na were examined. Groups of 31 male F344/DuCrj rats were given 1.25% OPP in the diet (group 1), 1.25% OPP in the diet plus 0.4% sodium bicarbonate (NaHCO3) in drinking-water (group 2), 2% OPP-Na in the diet (group 3) or 2% OPP-Na in the diet plus 1% ammonium chloride (NH4Cl) in drinking-water (group 4) for 26 wk. Urinary bladder tumours, papilloma and carcinoma occurred in 12/31 (39%) of group 1, 20/31 (65%) of group 2, 22/31 (71%) of group 3 and 3/31 (10%) of group 4. Values of urinary pH after 25 wk of treatment were correlated with the tumour incidences. The results indicate that the administration of an alkalizer enhanced the carcinogenicity of OPP and the administration of an acidifer inhibited the carcinogenicity of OPP-Na to the rat urinary bladder. This suggests that the earlier finding that OPP-Na was more carcinogenic than OPP resulted from the higher alkalinity of OPP-Na.

References

Mar 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FujiiK Hiraga
Jan 1, 1971·Journal of Theoretical Biology·C D Cone
Nov 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Hiraga, T Fujii
Mar 1, 1984·The Journal of Cell Biology·C P Burns, E Rozengurt

❮ Previous
Next ❯

Citations

Feb 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C B FrederickF F Kadlubar
May 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A P de GrootH R Immel
Jun 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A ShibataS Fukushima
Nov 15, 1989·Cancer Letters·R L Anderson
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B A R Lina, M H M Kuijpers
Feb 7, 2009·PPAR Research·Martin B OleksiewiczFrederikke L Egerod
Feb 27, 2016·Environmental and Molecular Mutagenesis·S BalakrishnanD A Eastmond
Oct 1, 1991·Regulatory Toxicology and Pharmacology : RTP·D B Clayson, D J Clegg
Apr 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Balakrishnan, D A Eastmond
May 15, 2013·The Journal of Toxicological Sciences·Yuichiro NakataTakuya Sugahara
Dec 19, 2002·Critical Reviews in Toxicology·E M BomhardM Richter
May 16, 2002·Journal of Agricultural and Food Chemistry·Shouxun ZhaoGeorge Eadon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.