Effects of Pharmacologic Dose of Resveratrol Supplementation on Oxidative/Antioxidative Status Biomarkers in Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Advanced Pharmaceutical Bulletin
Somayyeh AsghariMohammad-Hossein Somi

Abstract

Purpose: Despite a proposed role for oxidative stress in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), antioxidant approaches have not been sufficiently investigated in human NAFLD management. Resveratrol has been reported to possess a wide range of biological functions, including antioxidant activities. This study aimed to evaluate the effects of resveratrol supplementation on oxidative/anti-oxidative status in patients with NAFLD. Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted on 60 patients with NAFLD (males and females) aged 20 to 60 years, and body mass index (BMI) of 25-35 kg/m2. Subjects were randomly assigned to receive a daily dose of 600 mg resveratrol (2×300 mg pure trans-resveratrol capsules; n=30) or placebo capsules (n=30) for 12 wk. Fasting blood samples, anthropometric measurements, and dietary intakes were collected for all patients at baseline and at the end of the trial. Oxidative stress was evaluated by measurement of serum malondialdehyde (MDA), oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), and erythrocyte superoxide dismutase (SOD) as well as glutathione peroxidase (GSH-Px) activities. Changes in the outcomes were an...Continue Reading

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Citations

Nov 19, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Mahsa OmidianMaryam Mahmoudi
Jan 3, 2020·European Journal of Gastroenterology & Hepatology·Eduardo E Vargas-Pozada, Pablo Muriel
Oct 4, 2020·Pharmaceuticals·Jenifer TrepianaMaría Puy Portillo
Feb 8, 2021·International Immunopharmacology·Jue WangNan Wang
Apr 20, 2021·Frontiers in Oncology·María Zenaida Saavedra-LeosMacrina Beatriz Silva-Cázares
Jun 29, 2021·Expert Review of Gastroenterology & Hepatology·Sophia Seen
Jul 3, 2021·International Journal of Molecular Sciences·Shiyao ZhangSiyu Chen
Jul 20, 2021·The Cochrane Database of Systematic Reviews·Oluyemi KomolafeKurinchi Selvan Gurusamy
Aug 24, 2021·BMC Complementary Medicine and Therapies·Qiangqiang LiWayne Yuk-Wai Lee

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
MDA

Software Mentioned

Nutritionist
SPSS

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