Effects of pharmacological doses of Vitamin D3 on mineral balance and profiles of plasma Vitamin D3 metabolites in horses

The Journal of Steroid Biochemistry and Molecular Biology
Johein Harmeyer, Christina Schlumbohm

Abstract

Metabolism and functions of Vitamin D in horses differ from those in humans, pigs and rats. In horses, calcidiol and calcitriol concentrations in blood plasma are remarkably low (<10 nmol L(-1); 20-40 pmol L(-1), respectively). When a toxic amount of Vitamin D(3) is administered, the responsiveness of calcium and calcitriol concentrations in blood plasma is much reduced compared to the other domestic animal species but inorganic phosphate (Pi) response is much more marked, leading to an increase of the Ca x Pi product. Also, soft tissue calcifications have been observed to develop in horses during Vitamin D(3) intoxication. It was suggested that the elevation of the Ca x Pi product may play a causative role in this calcification process. To test this assumption, two horses were treated with 40,000 IU kg(-1) of Vitamin D(3) whilst dietary uptake of Ca and Pi was restricted to prevent or to diminish the increase of the Ca x Pi product. Distribution, number and severity of calcification centres were considerably less in these horses than in the control animals of a previous experiment which had received the same amount of Vitamin D(3) but where Ca and Pi intake was not restricted. It appears from these findings that in horses, the...Continue Reading

References

Feb 1, 1985·Clinical Science·E B MawerM Davies

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Citations

May 10, 2013·Sports Medicine·Daniel S MoranHarris R Lieberman
Sep 26, 2013·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Gerda R van SonsbeekWillem Schaftenaar
Dec 7, 2007·The Veterinary Clinics of North America. Equine Practice·David G Schmitz
Sep 9, 2015·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·F BockischI Vervuert
Aug 28, 2012·The Veterinary Journal·Keren Dittmer
Jun 1, 2016·PloS One·Ignacio LopezEscolástico Aguilera-Tejero
Mar 27, 2020·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Sara E Childs-SanfordJoseph J Wakshlag
Sep 19, 2020·Metabolites·Emma A HurstRichard J Mellanby
Aug 12, 2008·The American Journal of Clinical Nutrition·Glenville Jones

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