Effects of pharyngeal cooling on brain temperature in primates and humans: a study for proof of principle

Anesthesiology
Yoshimasa TakedaKiyoshi Morita

Abstract

Pharyngeal cooling decreases brain temperature by cooling carotid arteries. This study was designed to evaluate the principle of pharyngeal cooling in monkeys and humans. Monkeys (n = 10) were resuscitated following 12 min of cardiac arrest. Pharyngeal cooling (n = 5), in which cold saline (5°C) was perfused into the cuff at the rate of 500 ml/min, was initiated simultaneously with the onset of resuscitation for 30 min. Patients (n = 3) who were in an intensive care unit were subjected to 30 min of pharyngeal cooling under propofol anesthesia. In the animal study, core brain temperature was significantly decreased compared with that in the control group by 1.9°C (SD = 0.8, P < 0.001) and 3.1°C (SD = 1.0, P < 0.001) at 10 min and 30 min after the onset of cooling, respectively. The cooling effect was more evident in an animal with low postresuscitation blood pressure. Total dose of epinephrine, number of direct current shocks, and recovery of blood pressure were not different between the two groups. The pharyngeal epithelium was microscopically intact on day 5. In the clinical study, insertion of the cuff and start of perfusion did not affect heart rate or blood pressure. Tympanic temperature was decreased by 0.6 ± 0.1°C/30 min ...Continue Reading

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Citations

Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Bridget A Harris, Peter J D Andrews
Jan 24, 2013·Anesthesiology·Yoshimasa TakedaKiyoshi Morita
Feb 7, 2018·Therapeutic Hypothermia and Temperature Management·Sachiko SatoHiroshi Morimatsu
Jul 18, 2019·Journal of Neurotrauma·John J WalshDaniel Coman
Jan 5, 2017·BMC Neuroscience·Jose R EguibarAndrew C Gallup
Jun 27, 2019·Perfusion·Seyed Mohammad SeyedsaadatDavid F Kallmes

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