PMID: 3760870Nov 1, 1986Paper

Effects of phenylalanine on the release of endogenous dopamine from rat striatal slices

Journal of Neurochemistry
J D MilnerR J Wurtman

Abstract

We examined the effect of phenylalanine (50-400 microM) on the electrically stimulated release of endogenous 3,4-dihydroxyphenylethylamine (dopamine or DA) from superfused rat striatal slices. In the absence of tyrosine, phenylalanine (25 microM) partially sustained DA release, but less well than an equimolar concentration of tyrosine. In the presence of tyrosine (50 microM), phenylalanine (in concentrations of greater than or equal to 200 microM) inhibited DA release into the superfusate. This inhibition was not associated with changes in tissue levels of tyrosine or DA, nor was it mimicked by addition of high concentrations of tyrosine or leucine to the medium. We conclude that phenylalanine is a less effective precursor of DA in rat striatum than tyrosine and that it can also act to inhibit DA synthesis, depending on its concentration.

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Citations

Jan 1, 1989·Journal of Neural Transmission·L A ConlayG Evoniuk
Jan 1, 1987·Journal of Neural Transmission·R J Wurtman, T J Maher
Feb 6, 2007·Advances in Therapy·Kenneth BlumManuel Martinez-Pons
May 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M RomanoM Salmona
Dec 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G GuisoM Salmona
Feb 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L DiomedeM Salmona
Oct 31, 1988·Neuroscience Letters·M J DuringR J Wurtman
Dec 1, 1988·Toxicology Letters·C PeregoS Garattini
Oct 1, 1990·The Journal of Nutritional Biochemistry·J D Fernstrom
Nov 1, 1987·Environmental Health Perspectives·T J Maher, R J Wurtman
Aug 12, 2009·The International Journal of Neuropsychopharmacology·Tiziana PascucciSimona Cabib
May 8, 2016·Behavioural Brain Research·Flavia Maria SuteraFulvio Plescia
Jun 10, 2010·Journal of Psychopharmacology·Fabiana da Silva AlvesTherese van Amelsvoort
May 22, 2007·The Journal of Nutrition·John D Fernstrom, Madelyn H Fernstrom
Sep 3, 1999·Journal of Inherited Metabolic Disease·J WeglageK Ullrich
May 1, 1992·Metabolism: Clinical and Experimental·H E CarlsonR Koch

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