Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses

American Journal of Veterinary Research
Shannon K ReedKevin G Keegan

Abstract

To assess effects of treatment with phenylbutazone (PBZ) or a combination of PBZ and flunixin meglumine in horses. 24 adult horses. 13 horses received nonsteroidal antiinflammatory drugs (NSAIDs) in a crossover design. Eleven control horses were exposed to similar environmental conditions. Treated horses received PBZ (2.2 mg/kg, PO, q 12 h, for 5 days) and a combination of PBZ and flunixin meglumine (PBZ, 2.2 mg/kg, PO, q 12 h, for 5 days; flunixin meglumine, 1.1 mg/kg, IV, q 12 h, for 5 days). Serum samples were obtained on day 0 (first day of treatment) and day 5, and total protein, albumin, and globulin were measured. 1 horse was euthanatized with severe hypoproteinemia, hypoalbuminemia, and colitis during the combination treatment. Comparisons revealed no significant difference between control horses and horses treated with PBZ alone. There was a significant difference between control and treated horses when administered a combination of PBZ and flunixin meglumine. Correction for horses with values >2 SDs from the mean revealed a significant difference between control horses and horses administered the combination treatment, between control horses and horses administered PBZ alone, and between horses receiving the combinati...Continue Reading

References

Sep 1, 1990·Journal of Veterinary Internal Medicine·L F KarcherJ M King
Jul 1, 1995·Journal of Veterinary Internal Medicine·N D CohenT S Taylor
Dec 10, 1999·The Veterinary Clinics of North America. Equine Practice·D E Freeman
Nov 13, 2001·American Journal of Veterinary Research·C BrideauC C Chan
May 3, 2003·Journal of the American Veterinary Medical Association·Samuel L JonesKristin Rowlingson
Jan 15, 2004·American Journal of Veterinary Research·Michael S O'ConnerNoah D Cohen
Jun 17, 2004·American Journal of Veterinary Research·Julia E TomlinsonAnthony T Blikslager
Oct 12, 2004·Preventive Medicine·Anton B P Staring, Marinus H M Breteler

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Citations

Aug 7, 2012·Journal of Veterinary Internal Medicine·G NobleS L Raidal
Jul 19, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Ursula BechertE Bendas
Nov 5, 2008·American Journal of Veterinary Research·Rebecca S McConnicoRustin M Moore
Aug 16, 2011·Journal of the American Veterinary Medical Association·Monica AlemanJamie K Higgins
Dec 7, 2007·The Veterinary Clinics of North America. Equine Practice·John Schumacher
Nov 26, 2009·Equine Veterinary Journal·J A Nadeau, F M Andrews
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·J A SchleiningA J Kind
Feb 22, 2013·Journal of Veterinary Internal Medicine·S L RaidalG K Noble
Dec 7, 2011·Equine Veterinary Journal. Supplement·J H Foreman, R Ruemmler
Jun 15, 2011·Journal of Veterinary Pharmacology and Therapeutics·L R SomaG M Maylin
Dec 1, 2013·Equine Veterinary Journal. Supplement·J H Foreman, R Ruemmler
Dec 21, 2013·Journal of Veterinary Pharmacology and Therapeutics·L KivettJ Wright
Sep 23, 2018·Journal of Veterinary Pharmacology and Therapeutics·Sonja AxmannKarin Zitterl-Eglseer
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Ursula BechertSumeia Mohammed
May 18, 2021·Journal of Equine Veterinary Science·G van GalenD Verwilghen

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