PMID: 8589504Aug 1, 1995Paper

Effects of phenylephrine on the contractile tension and cytosolic Ca2+ level in rat anococcygeus muscle

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
K ShimizuN Urakawa

Abstract

A contractile property of phenylephrine (PE), alpha 1 agonist, on rat anococcygeus muscle was compared with that on rat aorta by simultaneously measuring changes in intracellular Ca2+ ([Ca2+]i) level and muscle tension. (1) PE (0.1-30 microM) and high K+ induced a sustained increases in [Ca2+]i level and muscle tension of both the muscles. (2) An application of verapamil (10 microM) and EGTA (4 mM) decreased the PE- or high K(+)-increased tension and [Ca2+]i level in both the muscle, respectively. (3) A cumulative application of PE or high K+ to anococcygeus muscle and aorta exhibited a positive relationship between [Ca2+]i and developed tension. The developed tension by PE was greater than that by high K+ at the same level of [Ca2+]i only in the aorta. A difference of regression slopes in the relationship between [Ca2+]i level and muscle tension under PE- and high K(+)-treatments in aorta was significant, but that in anococcygeus muscle was not. (4) An application of PE to anococcygeus muscle in Ca2+ free medium elicited a small transient contractile tension and increase in [Ca2+]i level, but that to aorta showed a large and transient increase in both the parameters. (5) Phorbol ester, DPB (1 microM), did not affect muscle ten...Continue Reading

Citations

Jun 23, 2009·European Journal of Pharmacology·Ulisses V HipólitoCarlos R Tirapelli
Oct 17, 2014·The Journal of Veterinary Medical Science·Takeharu KanedaKazumasa Shimizu
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Carlos R TirapelliFernando B da Costa
Nov 9, 2010·The Journal of Pharmacy and Pharmacology·João Xavier AraújoIsac Almeida de Medeiros
Nov 14, 2006·European Journal of Pharmacology·Carolina A Restini, Lusiane M Bendhack
Jan 8, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Irfan Anjum
Sep 15, 2019·Biological Trace Element Research·Shahnawaz Ahmad WaniSeemi Farhat Basir

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