PMID: 3756541Jul 1, 1986Paper

Effects of phenylpropanolamine on gastric retention in the adult rat

Brain Research Bulletin
P J WellmanM D Strickland

Abstract

Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63, and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.

References

Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·P J Wellman, T L Sellers
May 1, 1983·Physiology & Behavior·R F DaviesA J Zolovick

❮ Previous
Next ❯

Citations

Sep 1, 1993·Physiology & Behavior·G MittlemanS E Winders
Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·P J Wellman, A Levy
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·P J Wellman, R Cockroft
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·B T Davies, P J Wellman
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·K M Hull, T J Maher
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·P J Wellman, B T Davies
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·K M Hull, T J Maher
Nov 1, 1987·Human Toxicology·D J Wilkinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.