Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Xiao Yan Mao, Shi Jie Tang

Abstract

Cleft lip and cleft palate are common congenital craniofacial birth defects in humans. Phenytoin (PHT) is a risk factor of cleft palate formation; however, the molecular mechanisms by which phenytoin exerts its teratogenic effects resulting in cleft palate remain unknown. The Satb2 gene mutation is associated with cleft palate. Satb2-deficient mice exhibit cleft palate deformity and an up-regulation of Hoxa2 in the fronto-nasal region. In this study, phenytoin was administered intraperitoneally to pregnant C57BL/6 mice on the 10th day of gestation. Real-time PCR results showed that the expressions of Satb2 and Hoxa2 in craniofacial tissues of mouse embryos were obviously different at different time points. The Satb2 gene was down-regulated and the Hoxa2 gene was up-regulated in phenytoin-treated mouse embryonic craniofacial tissue. We conclude that phenytoin may regulate the expression of these two genes in C57BL/6 mice and it may also be involved in the formation of cleft palate.

References

Jan 30, 1981·Science·R H Finnell
Jul 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V KaartinenC F Shuler
Jan 23, 1999·Free Radical Biology & Medicine·L M Winn, P G Wells
May 2, 2000·Cellular and Molecular Neurobiology·A NazaraliJ Yeung
Aug 14, 2003·Human Molecular Genetics·David R FitzPatrickDavid T Bonthron
Feb 7, 1964·Deutsche medizinische Wochenschrift·D JANZ, U FUCHS

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Citations

Sep 29, 2011·Yi chuan = Hereditas·Yan-Yan QianDuan Ma
Feb 4, 2014·International Journal of Pediatric Otorhinolaryngology·Yu LinShijie Tang
Jan 15, 2014·Cytokine & Growth Factor Reviews·Xiaoying ZhaoXiaoling Zhang
Oct 29, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liucheng WuYuan Lin
Feb 6, 2020·Experimental and Therapeutic Medicine·Wen-Lin XiaoNing Zhao
Feb 13, 2021·International Journal of Molecular Sciences·Hiroki YoshiokaJunichi Iwata
Dec 12, 2020·Frontiers in Cell and Developmental Biology·S T RatermanJohannes W Von den Hoff

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