PMID: 2105653Jan 1, 1990Paper

Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia

The American Journal of Physiology
K AtisookJ L Madara

Abstract

Glucose alters absorptive cell tight junction structure and, as deduced from an impedance analysis model, diminishes tight junction resistance in the small intestine (J.R. Pappenheimer, J. Membr. Biol. 100: 137-148, 1987; and J.L. Madara and J.R. Pappenheimer, J. Membr. Biol. 100: 149-164, 1987). Here we provide further evidence in support of this hypothesis using the conventional approach of analysis of mucosal sheets mounted in Ussing chambers. This approach offers advantages for investigating underlying mechanisms, including the effects of ions and inhibitors on the regulation of intercellular junctions by glucose. We show that phlorizin blocks a resistance decrease elicited by glucose and demonstrate that substitution of choline for sodium also prevents the response. The dilatations in absorptive cell tight junctions that accompany this glucose-elicited response are similarly prevented by phlorizin exposure or sodium substitution. The effects of phlorizin on junctional permeability can also be demonstrated in vivo. Phlorizin reduces the transjunctional flux of creatinine in glucose-perfused intestines of anesthetized animals, even when account is taken of the reduction of fluid absorption caused by phlorizin. Last, in vivo ...Continue Reading

References

Apr 1, 1989·The Journal of Clinical Investigation·J L Madara
Jan 1, 1987·The Journal of Membrane Biology·J L Madara, J R Pappenheimer
Mar 11, 1957·The Journal of Physiology·R M ATKINSOND H SMYTH
Oct 1, 1957·The Journal of Clinical Investigation·B BORGSTROMJ SJOVALL

❮ Previous
Next ❯

Citations

Jan 1, 1992·Annals of the New York Academy of Sciences·J L MadaraP Kaoutzani
Mar 10, 1999·The American Journal of Physiology·J S LaneS W Ashley
Nov 22, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Richard L WuJerrold R Turner
Feb 1, 1996·Digestive Diseases and Sciences·N CuiR N Fedorak
Sep 14, 1999·The American Journal of Physiology·J R TurnerJ L Madara
Nov 18, 2000·American Journal of Physiology. Cell Physiology·J R TurnerJ M Angle
Oct 8, 2008·The Journal of Physiological Sciences : JPS·Kukiat TudporNarattaphol Charoenphandhu
Jun 27, 2012·Annals of the New York Academy of Sciences·Le Shen
Nov 9, 2012·British Journal of Sports Medicine·Micah ZuhlPope Moseley
Apr 29, 2020·Nutrients·Ricard FarréGianluca Matteoli
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·András Kapus, Katalin Szászi
Oct 13, 2010·Annual Review of Physiology·Le ShenJerrold R Turner
Dec 25, 2015·American Journal of Physiology. Cell Physiology·Jeremy R Herrmann, Jerrold R Turner
Feb 8, 2020·International Journal of Molecular Sciences·Wei-Qi HeJerrold R Turner
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J J BerglundJ R Turner
Feb 16, 2006·The Journal of Membrane Biology·L González-MariscalS Hernández
Jul 8, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jonathan M Whittamore
Jun 27, 2012·Annals of the New York Academy of Sciences·Kevin E Cunningham, Jerrold R Turner
Oct 27, 1999·Journal of Gastroenterology and Hepatology·J M MariadasonP R Gibson
Feb 8, 2011·Antioxidants & Redox Signaling·Lena J JohnJörg-Dieter Schulzke
Dec 29, 2020·Frontiers in Nutrition·José João NameCarolina Parga Martins Pereira
Apr 19, 2020·Cellular and Molecular Gastroenterology and Hepatology·Li ZuoJerrold R Turner
Sep 1, 2000·Seminars in Cell & Developmental Biology·J R Turner
Jul 17, 1999·Pharmaceutical Science & Technology Today·A L Daugherty, R J Mrsny
Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J KarlssonP Artursson
Oct 26, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V TakafujiJ K Roche
Mar 1, 1996·The American Journal of the Medical Sciences·X Shi, C V Gisolfi
Sep 29, 2004·Toxicon : Official Journal of the International Society on Toxinology·Pamela MardonesNéstor Lagos
Dec 7, 2006·The American Journal of Pathology·Jerrold R Turner
Oct 5, 2007·Biochimica Et Biophysica Acta·Dan Yu, Jerrold R Turner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.