Effects of phosphate supplementation on Pseudomonas aeruginosa invasive behavior in burn wound infections: A simple approach to a big problem

Burns : Journal of the International Society for Burn Injuries
Soliman Mohammadi-SamaniNegar Azarpira

Abstract

This study was designed to investigate the effect of inorganic phosphate supplementation on invasive behavior of Pseudomonas aeruginosa in burn wound infections. An emulsion-based lotion containing sodium dihydrogen phosphate was formulated and then 50 female Sprague-Dawley rats with burn wounds were used to assess the effect of phosphate supplementation on swarming motility of P. aeruginosa. On the second day after burn, four groups of rats were inoculated with P. aeruginosa and one group was left as negative control. The treatment was started on day 3 and the animals were followed up for 4 weeks. Significant improvement in wound healing was observed in the phosphate-receiving group after the 4-week follow-up, compared to the negative control, positive control, and silver sulfadiazine-receiving groups. Histopathological assessment of the tissue samples also indicated the healing process in phosphate-enriched lotion receiving group. The results showed that inorganic phosphate supplementation results in alteration of the virulence behavior of P. aeruginosa and improvement in the wound healing process. In conclusion, phosphate supplementation would be a rational strategy in the eradication of P. aeruginosa wound infection.

References

Nov 24, 2001·Burns : Journal of the International Society for Burn Injuries·D MikusT Anic
Jun 7, 2003·Molecular Microbiology·Mikkel KlausenTim Tolker-Nielsen
Mar 29, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Amanda E HodleRosie M Thompson
Dec 2, 2006·Burns : Journal of the International Society for Burn Injuries·Bishara S AtiyehSaad A Dibo
Apr 8, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Frederick W Fuller
Apr 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alexander ZaborinJohn C Alverdy
Jun 2, 2009·Current Microbiology·Muayad M AbboudAmjad Al Tarawneh
Feb 4, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Lucía FernándezRobert E W Hancock
Jun 15, 2011·Trends in Microbiology·Elena B M BreidensteinRobert E W Hancock
Nov 22, 2011·Burns : Journal of the International Society for Burn Injuries·Yang FuZhaoFan Xia
Mar 13, 2012·Photochemistry and Photobiology·Maria C E HashimotoMartha S Ribeiro
Aug 18, 2012·Interdisciplinary Perspectives on Infectious Diseases·Victoria HamrahiEdward A Carter
Aug 24, 2012·International Journal of Nanomedicine·Sharif M AbdelghanyChristopher J Scott
Mar 13, 2013·The Journal of Surgical Research·David P NicholsJerry A Nick
Jun 6, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Zjir M RashaanRoelf S Breederveld

❮ Previous
Next ❯

Citations

May 18, 2020·Microbial Pathogenesis·S L Rajasekhar KarnaKai P Leung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.