PMID: 8947502Nov 15, 1996Paper

Effects of phosphatidylethanolamines on the activity of the Ca(2+)-ATPase of sarcoplasmic reticulum

The Biochemical Journal
A P StarlingA G Lee

Abstract

ATPase activities for the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum reconstituted into dioleoylphosphatidylethanolamine [di(C18:1)PE] are, at temperatures higher than 20 degrees C, lower than in dioleoylphosphatidylcholine [di(C18:1)PC], whereas in egg yolk phosphatidylethanolamine the activities are the same as in di(C18:1)PC up to 25 degrees C, suggesting that low ATPase activities occur when the phosphatidylethanol-amine species is in the hexagonal H11 phase. ATPase activities measured in mixtures of di(C18:1)PC and di(C18:1)PE do not change with changing di(C18:1)PE content up to 80%. It is concluded that curvature frustration in bilayers containing di(C18:1)PE has no effect on ATPase activity. The rates of phosphorylation and of Ca2+ transport are identical for the native ATPase and for the ATPase in di(C18:1)PE. Dephosphorylation of the phosphorylated ATPase in di(C18:1)PE at 25 degrees C is, however, slower than for the native ATPase, explaining the lower steady-state rate of ATP hydrolysis; in egg yolk phosphatidylethanolamine at 25 degrees C the rate of dephosphorylation is equal to that for the unreconstituted ATPase. Phosphorylation of the ATPase by P1 in the absence of Ca2+ is unaffected by reconstitut...Continue Reading

Citations

Aug 17, 2001·Biomedical Chromatography : BMC·S UchiyamaK Imai
Jul 22, 2015·The Journal of Membrane Biology·Val Andrew FajardoA Russell Tupling
Mar 12, 2013·Chemistry and Physics of Lipids·Elizabeth J Denning, Oliver Beckstein
May 20, 2009·The Journal of Chemical Physics·Anna C V Johansson, Erik Lindahl
Nov 27, 2009·Journal of the Royal Society, Interface·Jens A LundbaekOlaf S Andersen
Aug 2, 2006·Molecular BioSystems·Anthony G Lee
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·P V EscribáJ A García-Sevilla
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Jun 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Idlir LikoCarol V Robinson
Jan 22, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Bruno StiegerKaspar P Locher
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Dec 15, 2000·Cell Calcium·E C ToescuA Verkhratsky
May 6, 2003·Biochimica Et Biophysica Acta·A G Lee
Nov 3, 2004·Biochimica Et Biophysica Acta·Anthony G Lee

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