Effects of phosphatidylserine-containing supported lipid bilayers on the polarization of macrophages

Journal of Biomedical Materials Research. Part a
Hongxuan QuanHyeong-Cheol Yang

Abstract

Placement of dental implants initiates inflammatory foreign body response, in which macrophages play a central role and affect the subsequent tissue healing process such as bone formation. The purpose of this study was to fabricate phosphatidylserine (PS)-containing supported lipid bilayers (SLBs) on a titanium surface to regulate the polarization of macrophages, a critical factor that affects following tissue healing and regeneration. The fluorescent recovery after photobleaching images showed that the percentage of PS had a critical influence on the fluidity, and 20% PS had the highest fluidity. Furthermore, more expanded and elongated cells were observed in the SLB-coated groups. transforming growth factor-β1 and vascular endothelial growth factor, the key cytokine markers of M2 macrophage polarization, were increased in the SLB-coated groups, especially in the 20% PS group. Consistently, cells cultured on the SLB-coated titanium exhibited the distribution of CD206+ , which is a M2 macrophage specific maker. The results of this study demonstrated M2 polarization of macrophages on PS-SLB-coated titanium discs, which suggests the application of PS-SLB as an immune-regulating coating material to improve tissue reactions to dent...Continue Reading

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Citations

Jun 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongxuan QuanHyeong-Cheol Yang
Sep 10, 2021·Journal of Cancer Research and Clinical Oncology·Jie ZhangDong Tang

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