Effects of phospholipase A2 on lumbar nerve root structure and function

Spine
C ChenA I King

Abstract

To investigate the effects of phospholipase A2 on the neurophysiology and histology of rat lumbar spinal nerves and the corresponding behavioral changes. To study possible mechanisms of sciatica. The pathophysiology of sciatica is uncertain, although mechanical, chemical, and ischemic factors have been proposed. Phospholipase A2 was injected into the rat L4-L5 epidural space, and the rats were observed for 3 or 21 days. Behavioral studies were conducted daily during the survival period. On the 3rd or 21st day, extracellular nerve recordings were made from dorsal roots, to determine discharge properties and mechanical sensitivity. The nerve roots were then sectioned for a light-microscopic examination. Motor weakness of hind limbs and altered sensation were observed. In the 3-day phospholipase A2 groups, squeezing the dorsal roots at the L4-L5 disc level (force = 0.8 g) evoked sustained ectopic discharge that lasted approximately 8 minutes. Squeezing the roots distal to the L4-L5 area did not result in sustained discharges. In sham, control, and 21-day phospholipase A2 groups, squeezing the dorsal roots elicited only a transient firing that lasted approximately 0.1 second. Loss of myelin was seen in the nerve root cross sections...Continue Reading

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Citations

Aug 4, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Srinivasu KallakuriJohn M Cavanaugh
Oct 26, 2001·Current Pain and Headache Reports·K A Mulligan, J C Rowlingson
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·C F P TeixeiraY Cury
May 3, 2003·Toxicon : Official Journal of the International Society on Toxinology·M ChacurY Cury
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Joel G Pickar
Jun 15, 2006·The Clinical Journal of Pain·YiLi Zhou, Salahadin Abdi
Mar 19, 2014·PloS One·Abdelilah el BarzouhiUNKNOWN Leiden–The Hague Spine Intervention Prognostic Study Group
Dec 24, 2011·AJNR. American Journal of Neuroradiology·W M ByunM-W Ahn
Dec 5, 2006·Journal of Manipulative and Physiological Therapeutics·Gregory CramerJoel Pickar
Aug 27, 2015·The Journal of Manual & Manipulative Therapy·Adriaan Louw, Stephen G Schmidt
Jul 9, 2005·Archives of Physical Medicine and Rehabilitation·Michael J DePalmaCurtis W Slipman
Feb 27, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ralf Dirk RothoerlAlexander Brawanski
Jun 30, 2012·British Journal of Neurosurgery·Chaoyang ChenPrasanna Malaviya
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Jul 14, 2017·Anesthesia and Analgesia·Charles A OdonkorSteven P Cohen
Jun 4, 2010·European Journal of Anaesthesiology·Oonagh T HickeyGeorge D Shorten
Dec 18, 2002·Spine·Conor W O'NeillDeaglán P Ryan

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