Feb 1, 1976

Effects of phosvitin on the ecg changes induced under hypoxia in the rat

The Journal of Pharmacy and Pharmacology
L CaprinoF Borrelli


The effect of phosvitin (1 g kg(-1), i.p.) on ecg changes induced in rats by a reduction of partial oxygen pressure in the respiratory mixture was studied. Phosphocreatine, phosphoserine, ATP and Na2HPO42H2O were also administered intraperitoneally for comparison. Phosvitin alone was found to prevent the hypoxia-induced T-wave changes (flattening or disappearance), which were also temporarily aggravated by injection of noradrenaline. As to the metabolic, hypoxia-induced myocardial changes, two hypotheses are discussed: a release of phosvitin phosphate radicals ready for immediate utilization or a drug action mediated via a membrane-bound intrinsic proteinkinase system.

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Mentioned in this Paper

Metabolic Process, Cellular
Myocardial Contraction
Diastolic Blood Pressure
Egg White Proteins
Phosphate Measurement
Radicals (chemistry)
Norepinephrine, (+, -)-Isomer

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