Effects of Photobiomodulation on Degranulation and Number of Mast Cells and Wound Strength in Skin Wound Healing of Streptozotocin-Induced Diabetic Rats

Photomedicine and Laser Surgery
Mohammad BagheriMohammad Bayat

Abstract

A lack of effective treatments still exists for patients suffering from diabetes mellitus. Photobiomodulation is proved as a beneficial therapeutic modality for wounds. The aim of this study is to examine the effect of degranulation of mast cells and total number of mast cells in the remodeling step of an ischemic model of wound healing under the influence of photobiomodulation and conditioned medium (CM) from human bone marrow-derived mesenchymal stem cells (hBM-MSCs-CM), or CM, administered alone and or in combination. Initially, type 1 diabetes mellitus was induced in 72 male adult rats. Then, after a month, one incision was made on the back of each rat. Subsequently, the rats were divided into four groups. The first group was considered as the control (placebo) group, the second group received CM, the third group received photobiomodulation, and the fourth group received photobiomodulation+CM. On days 4, 7, and 15, samples were extracted from the wound for histological and tensiometric examinations. The total number of mast cells, including the three types of mast cells, was counted by the stereological methods. The tensiometric properties of the repairing tissue were examined. The administration of photobiomodulation and C...Continue Reading

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Citations

Oct 10, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Ann LiebertMichael R Hamblin
Jun 4, 2020·Journal of Molecular Histology·Gisela Rodrigues da Silva SassoManoel João Batista Castello Girão
May 28, 2019·Journal of Cellular Biochemistry·Farzaneh ChehelcheraghiMohammad Bayat
Feb 26, 2020·Journal of Tissue Engineering and Regenerative Medicine·Ana Laura Martins de AndradeNivaldo Antonio Parizotto
Feb 23, 2021·Aesthetic Plastic Surgery·Hernán PintoElena Sánchez-Vizcaíno Mengual
Jul 3, 2021·BioMed Research International·Mohammad BayatFarzaneh Chehelcheraghi
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Trinidad Montero-VilchezSalvador Arias-Santiago
Nov 7, 2020·Lasers in Medical Science·Eliane Martins AmadioPaulo de Tarso Camillo de Carvalho
Dec 24, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Weijie CaiPei Han

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Methods Mentioned

BETA
amputations
light microscopy
dissector
flow cytometry

Software Mentioned

WinMDI

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