PMID: 9161843Mar 1, 1997Paper

Effects of Photofrin photodynamic action on mitochondrial respiration and superoxide radical generation

Free Radical Research
C SaletF Ricchelli

Abstract

Cyanide-resistant respiration increases after irradiation of isolated mitochondria in the presence of Photofrin. This suggests an enhancement of electron leakage which has been evaluated by measuring superoxide radical formation in submitochondrial particles incubated with 6 micrograms/ml Photofrin in the medium and irradiated with increasing doses of light at 365 nm. After a dose of 4.5 kJ/m2 has been delivered, superoxide generation increases by a factor of approximately 2.5 at the level of NADH dehydrogenase and by a factor approximately 1.5 in the cyt bc1 region. These effects have been compared with changes observed in NADH-, succinate- and ascorbate-driven respiration and their implications discussed.

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Citations

Apr 16, 1998·Journal of Photochemistry and Photobiology. B, Biology·D Kessel, Y Luo
Sep 8, 2001·Photochemistry and Photobiology·D Kessel, M Castelli
Sep 2, 2008·Journal of Photochemistry and Photobiology. B, Biology·Lyudmila V ChekulayevaIgor N Shevchuk
Sep 6, 2008·Journal of Photochemistry and Photobiology. B, Biology·Ján KlebanPeter Fedorocko
Jan 31, 2006·Journal of Photochemistry and Photobiology. B, Biology·Cathy McCullagh, Peter K J Robertson
Nov 1, 2002·The Journal of Biological Chemistry·Jakub GolabMarek Jakobisiak

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