Effects of photoperiod on estrogen receptor, tyrosine hydroxylase, neuropeptide Y, and beta-endorphin immunoreactivity in the ewe hypothalamus

Endocrinology
Donal C Skinner, A E Herbison

Abstract

The neural components underlying the influence of photoperiod upon reproductive functioning are poorly understood. In this study, we have used immunocytochemistry to examine whether changes in photoperiod may influence specific neuronal cell populations implicated in mediating gonadal steroid feedback actions on GnRH neurons. Short day (SD) exposed ewes in the midluteal stage of the estrous cycle and long day (LD) anestrous ewes were perfused in pairs and hypothalamic brain sections immunostained for tyrosine hydroxylase (TH), neuropeptide Y (NPY), beta-endorphin (betaE), and the estrogen receptor (ER). The number of ER-immunoreactive cells detected within the preoptic area, but not the hypothalamus, was approximately 20% higher (P < 0.05) in LD ewes compared with SD animals. The numbers of TH-immunoreactive neurons comprising the A12, A14, and A15 cell groups were not different between LD and SD ewes, and the percentage of A12 (approximately 15%) and A14 (approximately 25%) neurons expressing ERs was similarly unaffected by photoperiod. The number of betaE neurons detected in the arcuate nucleus was 50% lower (P < 0.05) in SD vs. LD ewes, whereas NPY-immunoreactive cell numbers in the median eminence were 300% higher (P < 0.05...Continue Reading

Citations

Aug 6, 2009·Cerebrospinal Fluid Research·Jean-Claude ThiéryBenoit Malpaux
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Aug 9, 2012·Frontiers in Neuroendocrinology·Martin J Kelly, Oline K Rønnekleiv
Mar 3, 2004·Annals of the New York Academy of Sciences·Jean-Claude Thiery, Benoit Malpaux
Dec 15, 2010·The European Journal of Neuroscience·Michael N LehmanRobert L Goodman
Aug 19, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chantacha AnukulkitchIain J Clarke
Apr 10, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ivan T DemchenkoClaude A Piantadosi
Aug 10, 2013·Endocrinology·Casey C NestorRobert L Goodman
Apr 27, 2016·The Journal of Comparative Neurology·Rajae TalbiValérie Simonneaux

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