Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

Journal of Biomedical Optics
Poliani OliveiraAna Claudia Muniz Rennó

Abstract

The aim of this study was to evaluate the effects of laser phototherapy on the degenerative modifications on the articular cartilage after the anterior cruciate ligament transection (ACLT) in the knee of rats. Eighty male rats (Wistar) were distributed into four groups: intact control group (IG), injured control group (CG), injured laser treated group at 10 J/cm(2) (L10), and injured laser treated group at 50 J/cm(2) (L50). Animals were distributed into two subgroups, sacrificed in 5 and 8 weeks postsurgery. The ACLT was used to induce knee osteoarthritis in rats. After 2 weeks postsurgery, laser phototherapy initiated and it was performed for 15 and 30 sessions. The histological findings revealed that laser irradiation, especially at 10 J/cm(2), modulated the progression of the degenerative process, showing a better cartilage structure and lower number of condrocytes compared to the other groups. Laser phototherapy was not able to decrease the degenerative process measured by Mankin score and prevent the increase of cartilage thickness related to the degenerative process. Moreover, it did not have any effect in the biomodulation of the expression of markers IL1β, tumor necrosis factor-α, and metalloprotein-13. Furthermore, las...Continue Reading

Citations

Sep 25, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Yuan LiXueyong Shen
Dec 14, 2019·Lasers in Medical Science·Tatiane Neiva Santos CastroCarla Roberta Tim
Jul 6, 2020·Advances in Therapy·Soheila GanjehJavid Mostamand
Apr 22, 2020·BMC Musculoskeletal Disorders·Cid André Fidelis de Paula GomesDaniela Aparecida Biasotto-Gonzalez
Jan 27, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Lorena Pacheco de Oliveira MartinsMurilo Xavier Oliveira

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