PMID: 8974836Dec 1, 1995Paper

Effects of PhXA41, a prostaglandin analogue, and PGF2 alpha on the corneal and intraretinal d.c. electroretinogram (ERG) of the albino rabbit eye

Current Eye Research
R Bragadóttir, S Jarkman

Abstract

PhXA41, a prostaglandin F2 alpha analogue, is a new drug alternative for medical treatment of glaucoma. From earlier studies, it is known that certain prostaglandins (pgs) exert an influence on the d.c. electroretinogram (ERG). In the present study, possible effects of intraocular perfusion with PhXA41 (free acid) or PGF2 alpha on the rabbit retina and retinal pigment epithelium (RPE) were evaluated. Unilateral vitrectomy was performed and a continuous intraocular perfusion was established, in which a reference solution was alternated with the test solution. In part one of the experiments, the corneal d.c. ERG and the standing potential of the eye (SP) were recorded from both eyes. In part two, vitreal and intraretinal d.c. ERG were recorded in the vitrectomized eye. PhXA41 and PGF2 alpha produced similar effects, i.e. a significant and reversible c-wave increase at concentrations of 1-10 micrograms/ml. No influence was found in the concentration interval 10-100 ng/ml. There were no changes in a- and b-wave amplitudes at any of the concentrations tested. At a concentration of 10 micrograms/ml, the SP increased significantly. The intraretinal d.c. ERG showed a large reduction of slow PIII accompanied by a small change in transep...Continue Reading

References

Aug 1, 1979·American Journal of Ophthalmology·L C MoorheadC A Garcia
Jun 1, 1985·Acta Ophthalmologica·Y HondaE Chihara
Oct 1, 1989·Documenta Ophthalmologica. Advances in Ophthalmology·S Jarkman
Oct 15, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·S Jarkman, K O Skoog
Feb 1, 1967·The American Journal of Physiology·M B Waitzman, C D King
Jan 1, 1995·Documenta Ophthalmologica. Advances in Ophthalmology·S Jarkman, R Bragadóttir
Jul 1, 1952·The American Journal of Physiology·W K NOELL

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Citations

Feb 3, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Naj A SharifTerry L Davis
Aug 27, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T L Davis, N A Sharif

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