Effects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Theerada TaesotikulTsuyoshi Yokoi

Abstract

Phyllanthus amarus, a commonly used medicinal herb, was investigated for possible herb-drug interactions. The effect on CYP3A-mediated drug metabolism in rats after single dose administration of P. amarus extract was investigated using midazolam (MDZ) as a probe substrate. The effect of multiple dose administration of P. amarus extract on activity and expression of various CYP isoforms were studied. Oral administration of P. amarus extract (800 mg/kg) 1 h before oral MDZ increased the C(max) and AUC(0--∞) of MDZ by 3.9- and 9.6-fold and decreased the clearance by 12%, but did not alter the pharmacokinetics of intravenous MDZ. Daily administration of P. amarus extract (200 or 800 mg/kg/day) for 15 days in rats increased the activity and expression of CYP3A and CYP2B1/2. In contrast, the activities and expressions of CYP1A, CYP2C and CYP2E1 were not significantly changed. The dual effects of P. amarus extract on CYP enzymes were demonstrated. Single dose administration of the extract increased oral bioavailability of MDZ through inhibition of intestinal CYP3A whereas repeated administration of the extract slightly induced hepatic CYP3A and CYP2B1/2 in rats, which suggested that herb-drug interactions by P. amarus may potentially ...Continue Reading

References

May 18, 1994·Biochemical Pharmacology·W TassaneeyakulJ O Miners
Sep 2, 1998·British Journal of Clinical Pharmacology·D G BaileyJ D Spence
Dec 5, 1998·Clinical Pharmacokinetics·J H Lin, A Y Lu
Oct 16, 1999·Therapeutic Drug Monitoring·M NakajimaY Kuroiwa
Feb 15, 2000·British Journal of Clinical Pharmacology·W TassaneeyakulY Yamazoe
Jun 22, 2000·Archives of Biochemistry and Biophysics·W TassaneeyakulY Yamazoe
Apr 12, 2001·Journal of Ethnopharmacology·M Elvin-Lewis
Apr 2, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B SripanidkulchaiT Matsushima
May 22, 2002·Journal of Ethnopharmacology·N V RajeshkumarRamadasan Kuttan
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Tsutomu KotegawaDavid J Greenblatt
Oct 31, 2002·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·J David Spence
May 11, 2004·Journal of Radiation Research·K B Hari Kumar, Ramadasan Kuttan
Mar 15, 2005·Clinical Pharmacokinetics·Shufeng ZhouHoward L McLeod
Jan 24, 2006·Life Sciences·Raman VenkataramananStephen Strom
Jan 31, 2006·Life Sciences·Dhananjay Pal, Ashim K Mitra
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Kuzhuvelil Bhaskarannair Hari Kumar, Ramadasan Kuttan
Sep 6, 2006·Planta medica·Vikneswaran Murugaiyah, Kit-Lam Chan
Oct 20, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wenxia ZhangLee-Yong Lim
May 30, 2008·Clinical Pharmacology and Therapeutics·R M FrankeA Sparreboom
Oct 14, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Narayan P YadavSuman P S Khanuja
Jul 7, 2009·Chemico-biological Interactions·Rajesh KrithikaSrinivasan Narasimhan
Jun 12, 2010·Journal of Pharmaceutical and Biomedical Analysis·Dalia A Hamdy, Dion R Brocks

❮ Previous
Next ❯

Citations

Mar 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Gregory OndiekiXin He

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Asian Natural Products Research
Manju SinghMadan Mohan Gupta
The Journal of Pharmacy and Pharmacology
Naphassamon SukhaphiromSuree Jianmongkol
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
K B H Kumar, R Kuttan
© 2022 Meta ULC. All rights reserved