Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity: Systematic Review and Meta-Analysis

Childhood Obesity
Felice SiricoDaria Nurzynska

Abstract

New findings on adipose tissue physiology and obesity-associated inflammation status suggest that modification of the adipokine level can be relevant for the long-term prevention of obesity-associated chronic disease. The scope of the present study was to investigate the effectiveness of physical exercise in reducing the systemic inflammation related to obesity in children. We conducted a systematic review with meta-analysis of controlled randomized trials, identified through electronic database search, which investigated the effect of physical exercise, without concomitant dietary intervention, on adiponectin, leptin, and/or other inflammatory markers in children up to age 18 years with a body mass index greater than the 95th percentile for age and sex. Seven trials were included in the meta-analysis, with a total of 250 participants. Compared with the control group without any lifestyle modification, the physical exercise resulted in a reduction in leptin [standardized mean difference (SMD) -1.13; 95% confidence interval (95%CI): -1.89 to -0.37; I2 = 79.9%] and interleukin-6 (SMD -0.84; 95%CI: -1.45 to -0.23, I2 = 0.9%) and an increase in adiponectin plasma concentration (SMD 0.69; 95%CI: 0.02-1.35; I2 = 74.3%). These results...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Apr 18, 1997·The Journal of Biological Chemistry·G MüllerG Preibisch
Jul 20, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D B AllisonS B Heymsfield
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J H LeeR A Price
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Jun 24, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M MaachiJ-P Bastard
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Antje BöttnerWieland Kiess
Mar 18, 2005·Journal of Applied Physiology·Anne Marie W Petersen, Bente Klarlund Pedersen
Apr 9, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Zehra AycanAysun Bideci
Dec 24, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M A T FlynnS C Tough
Jan 20, 2007·Journal of Applied Physiology·Borja GuerraJose A L Calbet
Mar 10, 2007·Scandinavian Journal of Medicine & Science in Sports·B K Pedersen
Jun 6, 2008·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Daniela A RubinAndrea M Haqq
Oct 18, 2008·British Journal of Sports Medicine·A BouassidaZ Tabka
Jun 23, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Katalin EderAndras K Fulop
Jun 27, 2009·Nutrition Research Reviews·Mary HarringtonRichard C Cottrell
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Nov 26, 2009·The Journal of International Medical Research·Kursat Karacabey
May 11, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Stefanie SchoppenCarmen Garcés
Jul 16, 2010·International Journal of Epidemiology·James WoodcockIan Roberts
Aug 31, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christine M Burt Solorzano, Christopher R McCartney
Sep 18, 2010·Trends in Endocrinology and Metabolism : TEM·Martin G MyersMichael W Schwartz
Feb 1, 2011·Annals of the New York Academy of Sciences·Yingfeng Deng, Philipp E Scherer
Nov 18, 2011·The New England Journal of Medicine·Markus JuonalaOlli T Raitakari
Mar 28, 2012·Hormones : International Journal of Endocrinology and Metabolism·Adeeb ShehzadYoung Sup Lee
Sep 29, 2012·Journal of Applied Physiology·Leslie H WillisWilliam E Kraus
Nov 28, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ludovic ZimmerlinAlbert D Donnenberg
May 21, 2013·Biochimica Et Biophysica Acta·Ruth B S Harris
Jun 20, 2013·Frontiers in Endocrinology·Hyokjoon Kwon, Jeffrey E Pessin
Aug 3, 2013·The Kaohsiung Journal of Medical Sciences·Tsu-Nai WangMeng-Chuan Huang
Sep 21, 2013·Biomarkers in Medicine·Anila JaleelHaris Hashim
Dec 4, 2013·Annals of Internal Medicine·Caroline K KramerRavi Retnakaran
Jan 21, 2014·Progress in Cardiovascular Diseases·Vaughn W BarrySteven N Blair
Sep 18, 2014·European Journal of Clinical Nutrition·F L LombardoM Caroli
Jul 26, 2015·Journal of Sports Sciences·Fabrício VasconcellosPaulo Farinatti
Dec 25, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ghazi RacilJeremy B Coquart
Mar 22, 2016·JRSM Cardiovascular Disease·Thang S Han, Mike Ej Lean
Aug 10, 2016·Jornal de pediatria·Rafael Machado MantovaniAna Cristina Simões E Silva
Dec 27, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A García-HermosoR Ramírez-Vélez

❮ Previous
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Citations

May 28, 2019·International Journal of Molecular Sciences·Sheetal ParidaDipali Sharma
Dec 6, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Felice SiricoAlessandro Biffi
Jun 26, 2020·Scandinavian Journal of Medicine & Science in Sports·Mousa Khalafi, Michael E Symonds
Aug 5, 2020·International Journal of Food Sciences and Nutrition·Kubra Isgin-AticiZehra Buyuktuncer
Mar 13, 2019·International Journal of Molecular Sciences·Hidekatsu Yanai, Hiroshi Yoshida
Sep 18, 2020·Animals : an Open Access Journal From MDPI·Alberto Muñoz-PrietoAsta Tvarijonaviciute
Dec 7, 2018·Current Opinion in Allergy and Clinical Immunology·Hanako Tajima, Ruby Pawankar
Jul 26, 2019·Pediatric Cardiology·Maurizio Giuseppe AbrignaniUNKNOWN Cardiovascular Prevention Area, Young Cardiologists Area, and Paediatric Cardiology Task Force of the Associazione Nazionale
Dec 10, 2019·American Journal of Medical Genetics. Part a·Talia ThompsonShanlee Davis
Aug 7, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ljiljana PlavsicDjuro Macut
Jun 10, 2020·International Journal of Environmental Research and Public Health·Stefano PalermiFelice Sirico
Nov 18, 2020·Scandinavian Journal of Medicine & Science in Sports·Simone J J M VerswijverenNicola D Ridgers
Jul 17, 2019·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Shirley D Martin, Lauri D John
Jan 29, 2021·Critical Reviews in Food Science and Nutrition·Mousa KhalafiAmir Akbari
Feb 19, 2021·European Journal of Sport Science·Eero A HaapalaTimo A Lakka
Aug 12, 2020·Clinical and Experimental Pediatrics·Ronald J Headid Iii, Song-Young Park
Jul 25, 2021·International Journal of Environmental Research and Public Health·Eugenia Murawska-CiałowiczAdilson Marques
Jul 31, 2021·Journal of the American College of Cardiology·Matthew NayorRavi V Shah
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Akhilandeshwari RavichandranNathalie Bock
Dec 7, 2021·Frontiers in Nutrition·Sarah HubnerKarsten Koehler
May 19, 2020·Cardiovascular & Hematological Agents in Medicinal Chemistry·Sibu P SahaThomas F Whayne

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