Effects of physical exercise versus rosiglitazone on endothelial function in coronary artery disease patients with prediabetes

Diabetes, Obesity & Metabolism
S DeschG Schuler

Abstract

We conducted a three-arm, parallel-group, randomized, controlled trial to compare the effects of rosiglitazone and physical exercise on endothelial function in patients with coronary artery disease and impaired fasting glucose or impaired glucose tolerance over a 6-month period. Group A received rosiglitazone tablets 8 mg daily (n = 16), group B underwent a structured physical exercise programme (n = 15) and group C served as a control group (n = 12). At baseline and after 6 months, brachial artery ultrasound imaging was performed to assess reactive flow-mediated dilation (FMD). Rosiglitazone treatment and exercise both led to significant improvements in insulin resistance at 6 months, whereas no change was observed in control patients. FMD improved significantly in physical exercise patients, whereas no change could be observed in patients receiving rosiglitazone or in the control group. Between-group comparisons also showed a significant relative improvement in FMD in exercise patients compared with rosiglitazone.

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Citations

Mar 23, 2013·Current Hypertension Reports·Fernanda R RoqueAna M Briones
Dec 23, 2015·European Journal of Clinical Pharmacology·Marko StojanovićMiroslav Radenković
Apr 23, 2015·PloS One·Teresa Balboa-CastilloPilar Guallar-Castillón
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Jun 5, 2019·Current Heart Failure Reports·Michael Johannes SchindlerMartin Halle
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Mar 29, 2019·Journal of Diabetes and Metabolic Disorders·Mahmoud Asle Mohammadi ZadehAbdolhamid Habibi
Jan 30, 2021·Journal of Cardiopulmonary Rehabilitation and Prevention·Jonathan MyersReed Humphrey

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