PMID: 108720Mar 14, 1979

Effects of physostigmine, scopolamine, and mecamylamine on the sleeping time induced by ketamine in the rat

Psychopharmacology
E M Figallo, L B Wingard

Abstract

Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same route. The ketamine-induced sleeping time was significantly prolonged by physostigmine and scopolamine, but not by mecamylamine. After the delayed injection of physostigmine, the ketamine sleeping time was longer. These results, although too preliminary for a mechanistic interpretation, suggest that multiple neurotransmitter systems, probably including the cholinergic system, are involved in the mechanism of action of ketamine-induced narcosis.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·D L Cheney, E Costa
Nov 1, 1972·Canadian Journal of Physiology and Pharmacology·R F CatchloveH Maretić
Nov 1, 1973·Anesthesia and Analgesia·R E HolzgrafeS M Mintz
Nov 25, 1968·JAMA : the Journal of the American Medical Association·R C Duvoisin, R Katz
Aug 1, 1965·The Journal of Experimental Zoology·P A SmithR C King
Sep 1, 1965·International Journal of Neuropharmacology·A Pazzagli, G Pepeu
May 1, 1967·Clinical Pharmacology and Therapeutics·E B Crowell, J S Ketchum

Related Concepts

Metazoa
Drug Interactions
Ketaset
Mecamylamine
Eserine
Isopto Hyoscine
Sleep, Slow-Wave
Rats, Laboratory

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