Effects of picotamide, an antiplatelet agent, on cardiovascular, events in 438 claudicant patients with diabetes: a retrospective analysis of the ADEP study

British Journal of Clinical Pharmacology
M MilaniM Maderna

Abstract

Picotamide is an antiplatelet drug which inhibits thromboxane A2 (TxA2) synthase and antagonizes TxA2 receptors. In the ADEP (Atherosclerotic Disease Evolution by Picotamide) trial, 2304 patients with peripheral obstructive arterial disease (POAD) were studied in a double-blind, placebo-controlled, 18-month, multicentre trial. In this study, 151 events (13.1%) occurred on placebo and 122 (10.6%) on picotamide (900 mg day-1). The relative risk reduction was 19%, (P = 0.056). This paper reports a post-hoc analysis in a subgroup of 438 diabetic patients (picotamide = 230; placebo = 208). There were 32 vascular events on placebo (15%) and 18 on picotamide (8%) (relative risk reduction: 48%; 95% CI = 26, 76; P = 0.022). The results of this retrospective analysis suggest that a prospective study to investigate events in claudicant patients with diabetes mellitus is warranted.

Citations

Jun 30, 2019·Current Cardiology Reports·Ajay Nair SharmaAilin Barseghian
Nov 18, 2006·Journal of Cardiovascular Pharmacology·Ting-Ting HongBenedict R Lucchesi
Jul 20, 2007·Internal and Emergency Medicine·F Violi, W Hiatt
Aug 12, 2004·Journal of Thrombosis and Haemostasis : JTH·P FerroniG Davì
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·D CapodannoD J Angiolillo
Apr 27, 2001·Expert Opinion on Investigational Drugs·J Geiger
Nov 25, 2004·Prostaglandins & Other Lipid Mediators·Hiroki TsukamotoJunichi Goto

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