Effects of Pimobendan on Prolonging Time to Rehospitalization or Frequency of Rehospitalization in Patients with Heart Failure: A Retrospective Cohort Study Using a Medical Administrative Database (PREFER Study)

Journal of Health Economics and Outcomes Research
Kazuhisa KodamaKoichi Nakao

Abstract

As approximately 24% of patients with chronic heart failure are rehospitalized within 1 year and heart failure is aggravated by repeated hospitalizations, greater importance was attached to the prevention of hospitalization. The objective of this study was to investigate the influence of pimobendan on rehospitalization of patients with advanced heart failure using a Japanese medical administrative database. From January 2010 to February 2018, patients hospitalized two or more times for heart failure were selected for analysis. The primary endpoint was the incidence of hospitalizations for heart failure during the follow-up period, which was compared between pimobendan prescription and non-prescription groups after propensity score matching. The total number of patients with heart failure included during the study period was 1 421 110 and we matched 276 patients in both groups. The incidence of rehospitalization throughout the period to completion of follow-up was 365.23/1000 people/yr (95% confidence interval [CI]: 327.78-402.69) in the pimobendan prescription group and 537.81/1000 people/yr (95% CI: 492.36-583.27) in the non-prescription group. The cumulative incidence at 365 days was significantly lower in the pimobendan pres...Continue Reading

References

May 10, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Effects of Pimobendan on Chronic Heart Failure Study (EPOCH Study)
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki TsutsuiUNKNOWN JCARE-CARD Investigators
Nov 7, 2007·The New England Journal of Medicine·John KjekshusUNKNOWN CORONA Group
Aug 1, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Miyuki Tsuchihashi-MakayaUNKNOWN JCARE-CARD Investigators
Mar 19, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoki SatoUNKNOWN TEND Investigators
May 17, 2013·International Heart Journal·Koji MuraiKyoichi Mizuno
May 7, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Yoshihiko Saito
Sep 12, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Ryoichi UshigomeUNKNOWN CHART-2 Investigators

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