Abstract
Since beta-blockers could affect lipid levels at the therapeutic dose range in hypertensive patients, a parallel 6-month randomized trial with pindolol (PDL) (16 pts.) and propranolol (PPL) (23 pts.) was designed (mean age = 55 + 7.1 years and 57 + 8.0 years; 9 males, 7 females and 15 males, 8 females, respectively). Total cholesterol, LDL and HDL fractions, and triglycerides (TGs) were determined before (washout phase) and during 1, 3, and 6 months of therapy. Patients were instructed to maintain their usual dietary habits. Daily drug doses were adjusted step by step to attain an optimal hypotensive effect (PDL 15-45 mg, PPL 180-240 mg). In the PPL-treated group, total cholesterol and LDL did not change significantly, HDL decreased (from 45.2 to 40.5 mg/dl, p less than 0.05) and TG increased (from 133 to 169 mg/dl, p less than 0.05). In the PDL group total cholesterol and LDL did not change either, but HDL increased (35.9 to 44.7 mg/dl, p less than 0.01) and TGs, were reduced (from 169 to 131 mg/dl, p less than 0.05). No dose-effect relationship was recorded. It is concluded that pindolol does not negatively influence HDL nor the TG blood lipid profile as does PPL. Accordingly, pindolol might be preferred to propranolol in the...Continue Reading
References
Apr 15, 1978·British Medical Journal·J ShawA S Hua
Oct 1, 1976·Metabolism: Clinical and Experimental·N TanakaT Kanehisa
Nov 1, 1976·The American Journal of Medicine·R P Ames, P Hill
Jun 1, 1985·Archives of Internal Medicine·M H Weinberger
Jun 15, 1985·Lancet·A AmeryF Forette
Feb 1, 1988·British Journal of Clinical Pharmacology·R J Northcote, D Ballantyne
Jan 1, 1987·Cardiology·O RománA Valenzuela
Oct 1, 1971·Postgraduate Medical Journal·D G BeeversJ E Harpur
Jul 5, 1980·Lancet·P LerenP G Lund-Larsen
Apr 17, 1982·British Medical Journal·J L DayC N Simpson
Feb 27, 1984·The American Journal of Medicine·N L LasserJ Stamler
Feb 27, 1984·The American Journal of Medicine·G GreenbergW E Miall
Sep 24, 1982·JAMA : the Journal of the American Medical Association
Jan 1, 1982·British Journal of Clinical Pharmacology·C PasottiS M Chierichetti
Jan 1, 1982·British Journal of Clinical Pharmacology·A LehtonenJ Niskanen
May 1, 1980·Clinical and Experimental Pharmacology & Physiology·J D EnglandM Carlton