Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects

Translational Research : the Journal of Laboratory and Clinical Medicine
Gianfranco PiccirilloAndrea Ghiselli

Abstract

Recent evidence shows that pink grapefruit juice, which is a recommended dietary addition that contains high amounts of the antioxidant flavonoid naringenin, prolongs the corrected QT (QT(c)), a noninvasive electrophysiological marker of spatial myocardial repolarization, and does so by inhibiting the rapid component of the delayed rectifier K+ current (I(Kr)). Prompted by the observation that all class III antiarrhythmic drugs inhibit this current, thereby sometimes provoking torsades de pointes, we compared the effects of a liter of freshly squeezed pink grapefruit juice with those of 2 commonly used class III antiarrhythmics amiodarone and sotalol on the major noninvasive markers of temporal variability in myocardial repolarization used to stratify the risk of sudden death from malignant ventricular arrhythmias. In 32 subjects, 10 with postischemic dilated cardiomyopathy, 12 with hypertensive cardiomyopathy, and 10 healthy, we assessed QT(c) and QT variability index (QTVI) after administration of fresh pink grapefruit juice, placebo, amiodarone, or sotalol. After pink grapefruit juice and sotalol, all these indexes increased significantly from values observed after placebo (P<0.05) and from values after amiodarone (P<0.05). ...Continue Reading

References

Jan 1, 1989·Progress in Cardiovascular Diseases·B N SinghR Kannan
Nov 15, 1996·Circulation·M H LehmannD J MacNeil
Oct 24, 1998·Journal of Cardiovascular Electrophysiology·W L AtigaR D Berger
Apr 21, 2001·Journal of Agricultural and Food Chemistry·P MattilaJ Kumpulainen
Aug 24, 2002·Science·Igor SplawskiMark T Keating
Oct 7, 2004·Journal of the American College of Cardiology·Mark C HaigneyUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II investigators
Oct 16, 2004·Circulation Research·Gordon F Tomaselli, Douglas P Zipes
Oct 18, 2005·Journal of Electrocardiology·Ramarao S LankipalliGan-Xin Yan
Dec 13, 2005·Journal of Internal Medicine·M R Rosen, I S Cohen
Dec 13, 2005·Journal of Internal Medicine·M E Anderson
Mar 24, 2007·American Journal of Epidemiology·Jennifer LinJoAnn E Manson

❮ Previous
Next ❯

Citations

May 7, 2011·British Journal of Pharmacology·András Varró, István Baczkó
Jan 30, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mathias BaumertPaul G A Volders
May 13, 2017·Natural Product Reports·Jadel M KratzJudith M Rollinger
Jul 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Marek Malik
Mar 28, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Gianfranco PiccirilloDamiano Magrì
Mar 18, 2021·European Journal of Pharmacology·Simona SaponaraMassimo Valoti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.