Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes

Diabetes Care
Ananda BasuRobert A Rizza


Pioglitazone, a peroxisome proliferator-activated receptor agonist and glipizide, an insulin secretagogue, are commonly used to treat type 2 diabetes. Our study was designed to examine the effects of pioglitazone versus glipizide on body water, body composition, and hemodynamic parameters in the presence of comparable glycemic control between groups. We studied 19 diabetic subjects randomly assigned to either 45 mg pioglitazone (n = 8) or 10 mg (median dose) glipizide (n = 11) for 12 weeks. Body water content was measured with deuterated water, body composition by dual-energy X-ray absorptiometry and computed tomography, and cardiac output and systemic vascular resistance by acetylene rebreathing technique both before and after therapy. Pioglitazone increased (P < 0.001 from baseline) total body water (+2.4 +/- 0.5 l) accounting for 75% of the total weight gain (+3.1 +/- 2.0 kg) but did not alter vascular endothelial growth factor concentrations. Total abdominal (-32.2 +/- 19 cm(2)) and visceral fat area (-16.1 +/- 8 cm(2)) tended to decrease with pioglitazone but increased (P < 0.02 for differences between groups) with glipizide (+38.4 +/- 17 cm(2) abdominal; +19.1 +/- 9 cm(2) visceral). Pioglitazone tended to reduce (P = 0.05...Continue Reading


Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·L D ThomasP R Schloerb
Feb 1, 1995·The American Journal of Clinical Nutrition·Michael D JensenP F Sheedy
Jul 20, 2002·Pharmacotherapy·Nancee V Niemeyer, Laurel M Janney
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·S FüllertT Konrad
Feb 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T M LarsenA Astrup
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jian SongCarolyn A Ecelbarger
Oct 27, 2004·Archives of Internal Medicine·Elaine ChiquetteMuhammad Abdul-Ghani
Nov 13, 2004·Obesity Research·Aaron M PotretzkeMichael D Jensen
Jan 5, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bhavani Prasad KotaBasil D Roufogalis
May 7, 2005·Metabolism: Clinical and Experimental·Madhu Kalia


May 18, 2010·Diabetes Technology & Therapeutics·G Derosa, Pamela Maffioli
Sep 26, 2009·Current Opinion in Lipidology·Hannele Yki-Järvinen
Oct 11, 2007·Diabetes, Obesity & Metabolism·David Russell-Jones, Rehman Khan
Mar 13, 2008·Diabetes, Obesity & Metabolism·Robin E Buckingham, A Hanna
Jun 28, 2007·International Journal of Clinical Practice. Supplement·G Derosa
May 22, 2007·International Journal of Clinical Practice·R Donnelly
Jun 6, 2009·International Journal of Clinical Practice·G Schernthaner
Jun 7, 2012·American Journal of Physiology. Endocrinology and Metabolism·Daniel M KeenanJohannes D Veldhuis
May 14, 2009·Vascular Health and Risk Management·Anthony Barnett
Jan 1, 2010·Clinical Medicine Insights. Endocrinology and Diabetes·Cyrus V Desouza, Vijay Shivaswamy
Jan 8, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anthony P MarshStephen B Kritchevsky
Jun 7, 2011·Expert Opinion on Pharmacotherapy·Thomas ForstAndreas Pfützner
Apr 22, 2008·Expert Opinion on Pharmacotherapy·C V RizosM S Elisaf
Dec 26, 2007·Current Medical Research and Opinion·S M BeardR A Malik
Dec 25, 2007·Current Medical Research and Opinion·Andrew J Krentz
Jun 15, 2007·Current Medical Research and Opinion·Anthony BarnettRachel Mann
May 24, 2011·Current Medical Research and Opinion·Stuart A RossRobert J Ligthelm
Aug 29, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Janaka Karalliedde, Robin E Buckingham
Apr 3, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·John DormandyPROactive investigators
Nov 27, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kjeld Hermansen, Lene S Mortensen
Apr 20, 2012·Trends in Endocrinology and Metabolism : TEM·Bertrand CariouBart Staels
May 28, 2011·Primary Care Diabetes·Melissa Scollan-Koliopoulos, Bleich David
Aug 2, 2008·Journal of Cardiac Failure·Kiran K Khush
Apr 22, 2008·Fundamental & Clinical Pharmacology·Pantelis A Sarafidis
Mar 1, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·N P E KadoglouM Alevizos
Mar 26, 2013·Diabetes, Obesity & Metabolism·A Consoli, G Formoso
May 28, 2009·Fundamental & Clinical Pharmacology·Jochen Seufert
Sep 23, 2014·Cell Metabolism·Raymond E SoccioMitchell A Lazar
Apr 9, 2016·Current Obesity Reports·Pornpoj Pramyothin, Kalypso Karastergiou
Feb 27, 2016·Diabetes, Obesity & Metabolism·Muhammad Abdul-GhaniM Abdul-Ghani
Jul 26, 2006·Blood Pressure·Pantelis A Sarafidis, Peter M Nilsson
May 27, 2015·Lancet·Richard E Gilbert, Henry Krum
May 11, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ananda BasuRobert A Rizza
Apr 25, 2012·International Journal of Cardiology·Alun David HughesSimon Alistair McGillivray Thom
Sep 7, 2016·Pharmacology & Therapeutics·Ilia GoltsmanZaid Abassi
Oct 2, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·John P H WildingGALLANT 7 Study Group
Oct 2, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Burkhard GökeGALLANT 8 Study Group
Feb 2, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Ralph A DeFronzoSteven E Nissen
Jul 19, 2013·Nutrients·Anoop Misra, Usha Shrivastava
Aug 18, 2017·Critical Reviews in Toxicology·Melissa A DavidsonDaniel Krewski
Dec 13, 2019·Expert Opinion on Investigational Drugs·Phuc LeNaim Alkhouri
Nov 27, 2019·International Journal of Molecular Sciences·Linda Wu, Jenny E Gunton
May 10, 2016·The Journal of Clinical Endocrinology and Metabolism·George A BraySteven R Smith
May 1, 2007·Expert Review of Endocrinology & Metabolism·Thomas Forst, Andreas Pfützner
Nov 25, 2019·The Journal of Nutritional Biochemistry·Yuzuru IizukaAkiyo Matsumoto
Apr 21, 2019·Journal of Diabetes and Its Complications·Mohammed E Al-SofianiRita R Kalyani

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