PMID: 6539932Jan 1, 1984Paper

Effects of piribedil and of d-amphetamine on locomotor activity in immature rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
C T Dourish, S J Cooper

Abstract

The effects of piribedil, a direct dopamine (DA) agonist, and of d-amphetamine, an indirect DA agonist, on locomotor activity in 28-day old rats have been investigated. d-Amphetamine (1,2 and 4 mg/kg) increased activity in a dose dependent manner whereas only a 40 mg/kg dose of piribedil significantly increased activity; low doses of piribedil (1.25-10.0 mg/kg) had no effect on activity. Since hyperactivity induced by a direct DA agonist, such as piribedil, is thought to reflect post-synaptic DA receptor activation, the results appear to indicate that post-synaptic DA receptor mechanisms are fully developed in 28-day old rats. In contrast, as low doses of piribedil which cause sedation in adult animals failed to decrease locomotor activity under the present experimental conditions, it seems that DA autoreceptors may not be well developed in 28-day old rats.

References

Jun 1, 1978·Behavioral Biology·R L IsaacsonD McClearn
Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·E Mogilnicka, V Klimek
Jul 7, 1978·Brain Research·D K ReinsteinR L Isaacson
May 1, 1975·Developmental Psychobiology·S K SobrianB A Pappas
Jan 1, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·B Costall, R J Naylor
May 1, 1969·European Journal of Pharmacology·M LaubieJ C Le Douarec
Feb 1, 1972·European Journal of Pharmacology·J MajL Gajda
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·C T Dourish
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·G GianutsosJ G Godfrey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.