PMID: 25783963Mar 19, 2015Paper

Effects of Plants and Isolates of Celastraceae Family on Cancer Pathways

Anti-cancer Agents in Medicinal Chemistry
Syed Nasir Abbas BukhariMohamed Ali Seyed

Abstract

The evaluation of crude drugs of natural origin as sources of new effective anticancer agents continues to be important due to the lack of effective anticancer drugs currently used in practice which are generally accompanied with adverse effects at different levels of severity. The aim of this concise review is to gather existing literature on anticancer potential of extracts and compounds isolated from Celastraceae species. This review covers six genera (Maytenus, Tripterygium, Hippocratea, Gymnosporia, Celastrus and Austroplenckia) belonging to this family and their 33 isolates. Studies carried out by using different cell lines have shown remarkable indication of anticancer activity, however, only a restricted number of studies have been reported using in vivo tumor models. Some of the compounds, such as triptolide, celastrol and demethylzeylasteral from T. wilfordii, have been extensively studied on their mechanisms of action due to their potent activity on various cancer cell lines. Such promising lead compounds should generate considerable interest among scientists to improve their therapeutic potential with fewer side effects by molecular modification.

Citations

Feb 9, 2016·European Journal of Medicinal Chemistry·Marvin J NúñezIsabel L Bazzocchi
Mar 30, 2020·Chemistry & Biodiversity·Lucienir Pains DuarteDjalma M Oliveira
Feb 24, 2017·European Journal of Nutrition·Nahla E El-AshmawyHend E Abo Mansour
Dec 7, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Guangkui YanJingdong Zhang

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