PMID: 9435638Jan 22, 1998Paper

Effects of plasma from hibernating ground squirrels on monocyte-endothelial cell adhesive interactions

The American Journal of Physiology
Y YasumaJohn M Hallenbeck

Abstract

Adhesion and subsequent penetration of leukocytes into central nervous system ischemic tissue proceeds via a coordinated inflammatory mechanism involving adhesion molecules at the blood-endothelium interface. Mammalian hibernation is a state of natural tolerance to severely reduced blood flow-oxygen delivery (i.e., ischemia). Hibernating thirteen-lined ground squirrels were investigated in an attempt to identify factors responsible for regulating this tolerance. Since leukocytopenia is closely associated with entrance into hibernation, the role of leukocyte adhesion to endothelium in this phenomenon was examined. Intercellular adhesion molecule-1 (ICAM-1) is expressed by endothelium and regulates interactions with circulating leukocytes that may result in margination or extravasation. ICAM-1 expression by rat cerebral microvascular endothelial cells (EC) cultured with plasma from hibernating (HP) or nonhibernating (NHP) thirteen-lined ground squirrels was dose dependently increased by HP and, to a lesser extent, by NHP. Treatment of EC with HP coincidentally induced significantly greater increases in monocyte adhesion to EC (37.2%) than were observed with NHP (23.9%). Study of the effects of HP and NHP on monocyte adhesion to E...Continue Reading

References

Jan 1, 1992·Free Radical Biology & Medicine·O PalluyG Modat
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·P M Kochanek, J M Hallenbeck
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·S C Helps, D F Gorman
Oct 1, 1990·Archives of Neurology·M Fisher, R Francis
Apr 1, 1990·Immunological Reviews·R S Larson, T A Springer
Nov 1, 1990·Archives of Neurology·J M Hallenbeck, A J Dutka
Apr 1, 1990·Surgical Neurology·U S VasthareR F Tuma
Mar 10, 1989·Journal of Immunological Methods·P M BathD G Hassall
Mar 1, 1989·Stroke; a Journal of Cerebral Circulation·A J DutkaJ M Hallenbeck
Feb 1, 1973·Comparative Biochemistry and Physiology. A, Comparative Physiology·W A Spurrier, A R Dawe
Jun 9, 1980·Brain Research·M SpatzM R Murray
Jan 1, 1980·International Review of Cytology·S G KolaevaF E Ilyasov
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Dec 1, 1994·General and Comparative Endocrinology·T BoswellG J Kenagy
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SlighA L Beaudet
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K U FrerichsJ M Hallenbeck
Apr 1, 1993·Stroke; a Journal of Cerebral Circulation·C E GrossM B Sporn
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
Sep 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·C L AtanassovM H Van Regenmortel
Apr 1, 1955·Physiological Reviews·C P LYMAN, P O CHATFIELD

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Citations

Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J PrendergastRandy J Nelson
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
May 22, 2016·Physiological Genomics·Scott T CooperMarshall Hampton
Dec 15, 2020·Biological Reviews of the Cambridge Philosophical Society·Zhe ShiXin-Min Liu
Jun 19, 2021·Neuroscience and Biobehavioral Reviews·Matteo CerriRoberto Amici

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