Effects of Plasma Proteins on the Transport and Surface Characteristics of Polysulfone/Polyethersulfone and Asymmetric Cellulose Triacetate High Flux Dialyzers

Artificial Organs
Tae Ryung KimA L Zydney

Abstract

Blood-membrane interactions can have a large impact on the performance of hemodialysis membranes, particularly for high flux membranes in which the membrane itself provides very low resistance to solute transport. The objective of this study was to examine the effects of exposure to serum on the solute clearance and convective sieving characteristics of high flux polysulfone (Optiflux F250NR), polyethersulfone (ELISIO-25H), and asymmetric cellulose triacetate (SOLACEA-25H) hemodialyzers using both vitamin B12 and a range of polydisperse dextrans. Zeta potential measurements were used to obtain additional insights into the changes in membrane surface properties. Exposure to serum in a simulated dialysis session caused a significant reduction in both solute clearance and sieving coefficients for the polysulfone/polyethersulfone dialyzers, particularly for the larger molecular weight solutes. In contrast, the transport characteristics of the asymmetric cellulose triacetate dialyzers were almost unchanged after exposure to serum. The zeta potential of the cellulose triacetate membrane became slightly more negative after exposure to serum, consistent with an adsorbed protein layer composed largely of albumin. The net result is that ...Continue Reading

References

Jul 31, 1998·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·B Kirschbaum
Aug 16, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·P C BartelsM J Nubé
Jun 3, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jiahui Shao, Andrew L Zydney
Dec 19, 2009·Seminars in Dialysis·Zhongping HuangWilliam R Clark
May 11, 2013·The International Journal of Artificial Organs·Adriana Boschetti-de-FierroBernd Krause
Dec 13, 2016·Contributions to Nephrology·Takashi Sunohara, Toshiaki Masuda
Nov 22, 2017·Blood Purification·Tae Ryung KimAndrew L Zydney

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Citations

Jan 27, 2019·Artificial Organs·Paul S Malchesky
Oct 1, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel Schneditz, John T Daugirdas

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