Effects of plastic-adherent dermal multipotent cells on peripheral blood leukocytes and CFU-GM in rats

Transplantation Proceedings
Shi Chunmeng, Cheng Tianmin

Abstract

Multipotent cells were isolated from the dermis of newborn rats by their adherence to plastic culture dishes. Morphological observations showed that most of these elements were fibroblast-like cells described as cultured dermal multipotent cells (DMCs). These cells express CD90, CD44, CD59, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1). They display the capacity to differentiate into cells with the phenotypic properties of osteocytes, adipocytes, chondrocytes, or neurons depending upon the specific inducing media. The confluent dermal multipotent cell layer supported and promoted the in vitro growth of colony-forming unit of granulocyte/macrophage progenitors (CFU-GM) as well as hematopoietic progenitor colonies. Transplantation of dermal multipotent cells into sublethally irradiated rats led to a significant increase of peripheral blood white cells nucleated cells, and CFU-GM colonies in the bone marrow. Fluorescence in situ hybridization analysis using a Y-chromosome-specific probe showed that dermal multipotent cells could engraft into bone marrow. However, they failed to differentiate into CD45-positive hematopoietic cells and to repopulate the hematopoietic system of lethally ir...Continue Reading

References

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Citations

Nov 27, 2008·Journal of the Royal Society, Interface·Mark R PlaczekAthanasios Mantalaris
Apr 30, 2009·Stem Cells and Development·Jaroslaw StaszkiewiczBarbara Gawronska-Kozak
Feb 28, 2007·Clinical Laboratory·Andreas PanskyEdda Tobiasch
Jun 10, 2011·Intensive Care Medicine·Soraia C AbreuPatricia R M Rocco
May 18, 2010·Journal of the American Academy of Dermatology·Klaus Sellheyer, Dieter Krahl
Jun 6, 2009·Ageing Research Reviews·Xiaobing Fu, Xiaoyan Sun
Jun 19, 2008·Experimental Dermatology·Katrin LorenzAugustinus Bader
Dec 17, 2009·Journal of Cutaneous Pathology·Klaus Sellheyer, Dieter Krahl
Jun 18, 2016·Cell Adhesion & Migration·Daria KuznetsovaElena Zagaynova
Jun 28, 2014·Cell Transplantation·Zelin ChenChunmeng Shi
Mar 9, 2006·Izvestiia Akademii nauk. Seriia biologicheskaia·O V PaniushinV I Starostin

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