PMID: 7479573Jun 1, 1995

Effects of platelet-activating factor antagonists WEB 2086 and BN 50730 on digoxin-induced arrhythmias

Pharmacology & Toxicology
I CakiciI Kanzik


Effects of platelet-activating receptor antagonists WEB 2086 (1.0-30.0 intravenously) and BN 50730 (10.0 intravenously) alone or in combination with CGS 8515 (a specific 5-lipoxygenase inhibitor, 0.3 intravenously) and Dazmegrel (a thromboxane synthase inhibitor, 1.0 intravenous infusion) on digoxin-induced arrhythmias were investigated in anaesthetised guinea-pigs. ECG, mean arterial blood pressure, heart rate and arrhythmias were recorded, starting 30 min. before digoxin administration and continuing for 60 min. afterwards. WEB 2086 (10.0 intravenously) reduced the mortality rate and arrhythmia score significantly compared to the control values. However, in combination with CGS 8515, it did not affect the mortality rate. BN 50730 (10.0 reduced the incidence of ventricular fibrillation and also arrhythmia score. BN 50730 in combination with Dazmegrel was reduced the arrhythmia score, incidence of ventricular fibrillation and mortality rate significantly, compared to control values. Digoxin-induced acute rise in mean arterial blood pressure was not affected by any of drug treatment except WEB 2086 (10.0 in combination with CGS 8515. Heart rate values did not differ ...Continue Reading


Oct 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I KanzikH Zengil
Jul 1, 1990·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H J MestT Rein
Apr 1, 1986·British Journal of Pharmacology·K Schrör, C Thiemermann
Apr 1, 1988·British Journal of Pharmacology·R M Tripathi, R Kaushal
Mar 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·J Casals-Stenzel
Sep 1, 1983·The Journal of Pharmacy and Pharmacology·E WeinhouseJ Posner


Feb 8, 2013·Current Heart Failure Reports·Paraskevi DetopoulouSmaragdi Antonopoulou
Mar 9, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A Tuncay DemiryürekS Altug
Mar 11, 2005·Autonomic & Autacoid Pharmacology·A Tuncay Demiryürek, S Demiryürek
May 5, 1998·Fundamental & Clinical Pharmacology·J A MartínezJ L Alvarez
Feb 12, 1999·Pharmacology & Toxicology·S AltugI Kanzik

Related Concepts

Cardiac Arrhythmia
Cavia porcellus
Platelet Activating Factor
Platelet Inhibitors

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.