Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems

Evidence-based Complementary and Alternative Medicine : ECAM
Su-Yeon ChoSoo-Jin Park

Abstract

The effects of platycodin D (PD) pretreatment were examined in reflux esophagitis (RE) induced rats. Sham, control, and omeprazole (OMP) group were pretreated with distilled water or OMP as a reference, respectively, and PD pretreated groups were given 3 different PD doses once a day for 7 days. One hour after last pretreatment, RE was induced by ligation of the forestomach and pylorus. At 8 h after operation, all animals were sacrificed. PD showed significant dose-dependent reduction of gastric secretion, myeloperoxidase activity, and RE lesion areas of esophagus and stomach mucosa. There was a reduction of lipid peroxidation in 2 doses of PD groups and elevation of antioxidant enzyme activity in all PD groups. Gastric hexose and sialic acid were significantly increased in PD groups, while collagen was reduced. Plasma histamine levels were significantly reduced in all PD groups, but not in the OMP group. Total invasive lesion sizes of esophagus and gastric fundus were significantly decreased in all PD groups. Thicknesses in esophagus of all PD groups were significantly decreased and thicknesses of funds were significantly increased except lowest PD dose. Therapeutic effects of PD on the esophageal and gastric lesions were show...Continue Reading

References

Mar 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Minami, H Yoshikawa
Sep 1, 1984·The American Journal of Physiology·A RobertN Kaplowitz
Oct 1, 1993·Physiological Reviews·A AllenE Kivilaakso
May 31, 2001·The American Journal of Clinical Nutrition·M R HarkeyR M Hackman
Aug 10, 2002·Journal of Ethnopharmacology·K SairamR K K Goel
Jun 26, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tsuyoshi Saeki, Tamotsu Nikaido
Jan 7, 2004·Cleveland Clinic Journal of Medicine·M Brian Fennerty
May 4, 2004·Journal of Ethnopharmacology·Ch V RaoP Pushpangadan
Aug 19, 2004·The American Journal of Chinese Medicine·Seong-Soo ChoiHong-Won Suh
Jan 22, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masayuki KitanoJunichi Hasegawa
Apr 29, 2005·International Journal of Clinical Practice·P Malfertheiner, B Hallerbäck
Apr 22, 2006·European Journal of Pharmacology·Hai Lin ZhaoYeong Shik Kim
Jun 13, 2008·European Journal of Pharmacology·Chandana Venkateswara Rao, Madhavan Vijayakumar
Oct 14, 2009·World Journal of Gastroenterology : WJG·Sae-Kwang KuSeong-Soo Roh
Nov 23, 2011·Nature Reviews. Gastroenterology & Hepatology·Arne Kandulski, Peter Malfertheiner
Dec 14, 2011·Chinese Journal of Integrative Medicine·Jun-Chao ChenQing-Shan Zheng
Apr 5, 2012·The Journal of Pharmacy and Pharmacology·Young-Min AhnByung-Cheol Lee

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