Abstract
According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS). However, the role of PM2.5 in the pathophysiology of CRS remains largely unknown. In this study, we investigated the effects of PM2.5 on nasal cilia, tissue remodeling, and mucus hypersecretion in a rabbit model of CRS. CRS rabbits were exposed to ambient PM2.5 via a PM2.5 inhalation exposure system. The degree of ciliary damage was evaluated using scanning electron microscopy (SEM). Histopathologic changes were determined using periodic acid-Schiff (PAS) staining of goblet cells and Masson trichrome (MT) staining for collagen in the nasal mucosa. MUC5AC expression was assessed by immunohistochemistry. PM2.5 exposure substantially aggravated ciliary disruption in rabbits with CRS. PM2.5 also significantly increased goblet cell hyperplasia and collagen deposition, as reflected by PAS and MT staining. The nasal mucosa of CRS rabbits displayed markedly elevated MUC5AC expression after PM2.5 exposure. Increases in ciliary disruption, nasal remodeling, and mucus hypersecretion may be the pathophysiologic mechanisms underlying the PM2.5-indu...Continue Reading
References
Dec 5, 2000·Environmental Health Perspectives·K E PinkertonM B Schenker
Mar 22, 2003·American Journal of Respiratory Cell and Molecular Biology·Jin DaiAndrew Churg
Apr 5, 2008·The Laryngoscope·Kai-Li LiangJen-Fu Lin
Jan 23, 2009·The Laryngoscope·Neil Bhattacharyya
Jun 8, 2010·The European Respiratory Journal·C A HewsonS L Johnston
Dec 3, 2010·The New England Journal of Medicine·John V Fahy, Burton F Dickey
Sep 10, 2011·Molecules and Cells·Young Ok KimKyoung Seob Song
Apr 1, 2006·Inhalation Toxicology·Miriam LemosPaulo H N Saldiva
Jul 24, 2012·Archives of Toxicology·Stéphanie ValArmelle Baeza-Squiban
Dec 12, 2012·Current Opinion in Allergy and Clinical Immunology·Ahmed BassiouniPeter-John Wormald
Oct 10, 2013·Inhalation Toxicology·Kensho IwanagaJason S Debley
Dec 10, 2013·Nature·Michelle G RoyChristopher M Evans
May 14, 2014·Biochimica Et Biophysica Acta·Anthony P Corfield
Oct 18, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·David I KasaharaStephanie A Shore
Jan 30, 2015·Allergy·J B ShiG Xu
May 23, 2015·International Forum of Allergy & Rhinology·Henry P BarhamRichard J Harvey
Jun 19, 2015·American Journal of Respiratory Cell and Molecular Biology·Koa HosokiSanjiv Sur
Mar 1, 2016·Allergy, Asthma & Immunology Research·Byeong Gon KimAn Soo Jang
Jun 2, 2016·The Tohoku Journal of Experimental Medicine·Zhicong HongCongrui Deng
Sep 4, 2016·Allergy·A G HirschB S Schwartz
Nov 24, 2016·Allergy·M YokotaH Nakajima
Jan 22, 2017·Cell and Tissue Research·Zhe Zhou-SuckowMarcus A Mall
Jan 31, 2017·Environmental Pollution·Lili MingXiangdong Li
Apr 1, 2017·Scientific Reports·Fang HePixin Ran
Apr 13, 2017·American Journal of Rhinology & Allergy·Zhi-Qiang GuoRu-Xin Zhang
Aug 30, 2017·The Science of the Total Environment·Xiaoqi WangZhe Lv
Sep 13, 2017·Scientific Reports·Lingmei HuangPixin Ran
Dec 7, 2017·International Forum of Allergy & Rhinology·Leila J MadyStella E Lee
Citations
Oct 30, 2018·International Forum of Allergy & Rhinology·Luo Zhang
Aug 28, 2020·American Journal of Rhinology & Allergy·Na SunRuxin Zhang
Mar 27, 2020·American Journal of Rhinology & Allergy·Na SunRuxin Zhang
Dec 8, 2020·Current Opinion in Allergy and Clinical Immunology·Gwanghui RyuHyun-Woo Shin
Aug 23, 2020·Ecotoxicology and Environmental Safety·Xiaotong WangXiaoping Li
Sep 10, 2021·Current Allergy and Asthma Reports·Evelyn M LelandMurugappan Ramanathan
Jan 12, 2022·Military Medicine·Trevor ElamMurugappan Ramanathan