Effects of pneumoperitoneum on tumor implantation with decreasing tumor inoculum

Diseases of the Colon and Rectum
J S WuJ W Fleshman

Abstract

The aim of this study was to determine the effect of pneumoperitoneum on the rate of trocar-site implantation with decreasing inoculum of cancer cells. A total of 0.5 ml of GW-39 human colon cancer cell suspensions at 1 percent (approximately 3.2 x 10(5) cells) and at 0.5 percent (approximately 1.6 x 10(5) cells; v/v) were injected into the abdomen of hamsters through a midline incision. Animals in each group were randomized to receive either pneumoperitoneum (1 percent = 33; 0.5 percent = 43) or not (1 percent = 32; 0.5 percent = 39). Gross and microscopic tumor implants were documented seven weeks later at four trocar sites. In the 1 percent group, pneumoperitoneum significantly increased trocar-site tumor implants from 50 to 71 percent (P < 0.001). Pneumoperitoneum also resulted in the following: 1) more frequent involvement of all four concurrent sites (38 vs. 10 percent; P < 0.02); 2) more frequent palpable tumors (13 vs. 5 percent; P < 0.01); 3) larger tumor mass (2.1 +/- 0.6 g vs. 0.2 +/- 0.1 g; P < 0.02). In the 0.5 percent group, pneumoperitoneum did not significantly increase trocar-site tumor implants, and it did not result in a larger tumor mass. The percent increase in trocar-site implants owing to pneumoperitoneum...Continue Reading

References

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Citations

May 19, 2001·Surgical Endoscopy·J E HartleyJ R Monson
Jul 10, 2001·Surgical Endoscopy·C BalagueC A Jacobi
Oct 8, 2003·Gynecologic Oncology·Pedro T RamirezCharles Levenback
Feb 17, 2000·Surgical Oncology·T M Young-Fadok
Mar 5, 2003·Annals of Surgery·Mario MorinoCorrado Garrone
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Dec 25, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y LiangJ Yu
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Oct 4, 2006·American Journal of Obstetrics and Gynecology·Chyi-Long Lee, Nari Kay
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Mar 1, 2016·Pleura and Peritoneum·Félix GremonprezWim Ceelen
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Chyi-Long LeeSiew Yen Lai
Sep 17, 2002·Journal of the American College of Surgeons·Paul ZiprinAra W Darzi

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