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Effects of point mutations in a hinge region on the stability, folding, and enzymatic activity of Escherichia coli dihydrofolate reductase

Biochemistry

Aug 6, 1991

P M Ahrweiler, C Frieden

PMID: 1868058

Abstract

The role of a hinge region in the folding, stability, and activity of Escherichia coli dihydrofolate reductase was investigated with three site-directed mutants at valine-88, the central residue of the hinge. The three mutants, V88A and V88I and a valine-88 deletion, were created to per...read more

Mentioned in this Paper

Thermodynamics
Apoenzymes
Alkalescens-Dispar Group
Enzymes, antithrombotic
Valine
Proteins, Recombinant DNA
Mutagenesis, Site-Directed
DHFR
Gene Deletion Abnormality
Plasma Protein Binding Capacity
Paper Details
References
  • References30
  • Citations17
12

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Effects of point mutations in a hinge region on the stability, folding, and enzymatic activity of Escherichia coli dihydrofolate reductase

Biochemistry

Aug 6, 1991

P M Ahrweiler, C Frieden

PMID: 1868058

DOI:

Abstract

The role of a hinge region in the folding, stability, and activity of Escherichia coli dihydrofolate reductase was investigated with three site-directed mutants at valine-88, the central residue of the hinge. The three mutants, V88A and V88I and a valine-88 deletion, were created to per...read more

Mentioned in this Paper

Thermodynamics
Apoenzymes
Alkalescens-Dispar Group
Enzymes, antithrombotic
Valine
Proteins, Recombinant DNA
Mutagenesis, Site-Directed
DHFR
Gene Deletion Abnormality
Plasma Protein Binding Capacity

Similar Papers Found In These Feeds

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Related Papers

Paper Details
References
  • References30
  • Citations17
12
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