Effects of polaprezinc on gastric mucosal damage and neurotransmitters in a rat model of chemotherapy-induced vomiting

The Journal of International Medical Research
Zhao Yang LiuZi Qiang Zhang

Abstract

Objective To investigate the effects of polaprezinc (PZ) on cyclophosphamide (CTX)- or cisplatin (DDP)-induced gastric mucosal injury and on a rat model of neurotransmitter-mediated vomiting. Methods Sprague-Dawley rats were divided at random into Control, CTX, DDP, PZ+CTX, and PZ+DDP groups. After 20 days, brain tissues and sera were analyzed for the levels of dopamine (DA), 5-hydroxytryptamine (5-HT), and nuclear factor kappa B (NF-κB). Hematoxylin and eosin-stained sections of stomach, intestine, and brain tissues were examined using light microscopy. Results The levels of DA, 5-HT, and NF-κB in brain and serum samples of rats treated with CTX or DDP were significantly increased compared with those of rats in the Control group. There was a significant decrease in these values in the PZ group. Moreover, PZ reduced damage to brain tissue caused by CTX or DDP. Conclusions PZ decreased the levels of DA, 5-HT, and NF-κB in blood and brain tissues caused by CTX or DDP and reduced the chemotherapy-induced damage to the small intestine, stomach, and brain. These findings can be translated to the clinic to enhance the efficacy and safety of chemotherapy.

References

May 5, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Dorthe CarlsonJakob Sehested
Jan 28, 2010·International Journal of Cancer. Journal International Du Cancer·Tomoko WatanabeYoshinori Itoh
May 22, 2010·Journal of Clinical Biochemistry and Nutrition·Shuzo OhataTatsuya Matsura
Nov 30, 2013·Scandinavian Journal of Gastroenterology·Munenori ItagakiHisao Tajiri
Dec 4, 2013·Journal of Medicinal Chemistry·Ferdinando FiorinoElisa Perissutti
Mar 5, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yosuke IkariKazuo Tamura
Mar 3, 2015·Journal of Pharmacological Sciences·Masahiro Murakami-NakayamaAtsufumi Kawabata
Jun 6, 2016·Journal of Pharmacological Sciences·Kuniaki TsutsumiNobuaki Egashira
Aug 19, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Declan WalshAlex Molassiotis
Sep 3, 2016·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MorganMiranda Hughes
Aug 24, 2017·The Journal of International Medical Research·Min-Kyun OhYoung Sook Park

❮ Previous
Next ❯

Citations

Nov 2, 2021·Experimental and Therapeutic Medicine·Mingru LiZhaoyang Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Assay

Software Mentioned

TECAN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.