PMID: 14417919May 1, 1960Paper

Effects of polarization of the receptor membrane and of the first Ranvier node in a sense organ

The Journal of General Physiology
W R LOEWENSTEIN, N ISHIKO

Abstract

It has previously been shown that the site of production of the generator potential in Pacinian corpuscles is the receptor membrane of the non-myelinated ending, and the site of initiation of the nerve impulse, the adjacent (first) Ranvier node. Effects of membrane polarization of these sites were studied in the present work. Nerve ending and first Ranvier node were isolated by dissection, electric activity was recorded from, and polarizing currents were passed through them. All observations were done at steady levels of polarization, seconds after onset of current flow. The following results were obtained: The amount of charge transferred through the excited receptor membrane is a function of the electrical gradients across the membrane. The generator potential in response to equal mechanical stimuli increases with resting potential of the receptor membrane. The refractory state of the generator potential is not affected by polarization. The electrical threshold for impulse firing at the first Ranvier node (measured by the minimal amplitude of generator potential which elicits a nodal impulse) is nearly minimal at normal resting potential of the node. Both, hyperpolarization and depolarization lead to a rise in nodal threshold...Continue Reading

Citations

Oct 1, 1982·Pflügers Archiv : European journal of physiology·S Terakawa, A Watanabe
Feb 24, 1976·Pflügers Archiv : European journal of physiology·O B IlyinskyS I Elman
Jan 1, 1982·Neir̆ofiziologiia = Neurophysiology·Iu A Chelyshev, R R Gataullin
Jan 1, 1977·Neir̆ofiziologiia = Neurophysiology·G N Akoev, Iu A Chelyshev
Nov 1, 1973·Neir̆ofiziologiia = Neurophysiology·I S Poshina
Jan 1, 1976·Neir̆ofiziologiia = Neurophysiology·I S PoshinaR A Durinian
Jan 1, 1973·Neir̆ofiziologiia = Neurophysiology·N P Alekseev
Jan 1, 1994·Progress in Neurobiology·J BellM H Holmes
Sep 1, 1961·The Journal of General Physiology·N ISHIKO, W R LOEWENSTEIN
Nov 1, 1964·The Journal of General Physiology·S HIGASHINO, S F TAKAGI
May 1, 1973·The Journal of General Physiology·D L Alkon, A Bak
Jul 14, 1966·Annals of the New York Academy of Sciences·T Teorell
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Waheeda A HossainD Kent Morest
Jan 1, 1993·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·S I Perlmutter, E Eldred
Sep 6, 1961·Annals of the New York Academy of Sciences·W R LOEWENSTEIN
Dec 16, 1960·Science·N ISHIKO, W R LOEWENSTEIN

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