PMID: 11910050Mar 23, 2002Paper

Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats

Experimental Biology and Medicine
Sandra M ThyssenC Libertun

Abstract

Polyamines, putrescine (PUT), spermidine (SPD), spermine (SPM), and agmatine (AGM), are polycationic amines related to multiple cell functions found in high concentrations during the development of hypothalamus and pituitary. In previous works, we demonstrated that alpha-difluoromethylornithine (DFMO), an inhibitor of polyamines biosynthesis, induced a delay in puberty of female rats, accompanied by high, sustained follicle-stimulating hormone (FSH) levels during the infantile period. Also, DFMO treatment induced changes in polyamine concentration both in hypothalamus and pituitary of rats, mainly a decrease of PUT and SPD, an increase in SPM, and no change in AGM. In the present work, we investigated the direct effects of polyamines on the secretion of hypothalamic GnRH and pituitary gonadotropins in 6- and 15-day-old female rats. In 6-day-old animals, in vitro incubations with PUT, SPD, and AGM of hypothalami or anterior pituitaries were able to inhibit GnRH, FSH, and leutinizing hormone (LH) secretion, respectively. SPM showed a nonspecific transient inhibitory effect on FSH. When challenged with either high K(+) (hypothami) or GnRH (pituitaries), the tissues incubated in the presence of polyamines showed no differences when...Continue Reading

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Citations

Jul 28, 2011·Endocrine Reviews·Pavine L C LefèvreBruce D Murphy
Oct 28, 2016·Journal of Translational Medicine·Lourdes Sánchez-SevillaRolando Hernández-Muñoz
Feb 11, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Joseph R D FernandesArnab Banerjee
Mar 21, 2017·General and Comparative Endocrinology·Joseph R D FernandesArnab Banerjee
Apr 6, 2021·Open Life Sciences·Dongmei JiangBo Kang

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