Effects of polychlorinated biphenyl mixtures and three specific congeners on growth and circulating growth-related hormones

General and Comparative Endocrinology
J C GouldC G Scanes

Abstract

Polychlorinated biphenyls (PCB) are ubiquitous environmental contaminants that bioaccumulate in avian species. Exposure to PCBs can result in decreased growth. Thyroid hormones and growth hormone (GH) are important for normal growth. The present studies employed the chicken embryo to investigate effects of Aroclor 1242, Aroclor 1254, 2,2',6,6'-tetrachlorobiphenyl (TCB), 3,3',4,4'-TCB, and 3,3',5,5'-TCB on growth and growth-related hormones. The following indices were measured: embryo mortality, body weights, bone length, pituitary GH content, and plasma concentrations of triiodothyronine (T3), thyroxine (T4), GH, and insulin-like growth factor-1 (IGF-1). Fertile eggs were injected with PCBs on Day 0 and indices determined on Day 17 of incubation. Unexpectedly, 3,3',5,5'-TCB or low-dose Aroclor 1242 treatment increased body weight and bone length (P < 0.05), whereas Aroclor 1242 (high dose), 3,3,4,4'-TCB, or Aroclor 1254 treatment reduced body weights and/or bone length (P < 0.05). Aroclor 1242 or 3,3',4,4'-TCB (low-dose treatment) elevated plasma T4 concentrations (P < 0.05). Both growth and pituitary GH content were increased (P < 0.05) by 3,3',5,5'-TCB (low dose) or Aroclor 1242 treatment. Despite marked differences in growth...Continue Reading

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Citations

Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Doug CrumpSean W Kennedy
Sep 29, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Even H JørgensenMathilakath M Vijayan
Dec 14, 2011·The Science of the Total Environment·Therese Haugdahl NøstBjørn Munro Jenssen
Sep 18, 2001·Toxicology and Applied Pharmacology·D ColettiS Adamo
Dec 24, 2013·Environment International·Muhammad Zaffar HashmiChaofeng Shen
Jul 23, 2003·Environmental and Molecular Mutagenesis·Anna M JelasoCharles F Ide
Oct 14, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·G GiusiD Santucci
Nov 17, 2010·Ecotoxicology·Jeffrey M Warren, Kyle A Cutting
Oct 30, 2020·Environmental Toxicology and Chemistry·Corinna SinglemanNathalia G Holtzman
Jun 22, 1999·Ecotoxicology and Environmental Safety·J C GouldC G Scanes
Feb 12, 2002·Neurotoxicology and Teratology·Mary Ann OttingerNichola Thompson
Sep 8, 2006·Environmental Science & Technology·Alejandro B Rodriguez-NavarroKaren F Gaines

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