Abstract
The effects of pure synthetic polychlorinated biphenyl (PCB) congeners on the induction of cytochrome P450 and associated activities were examined in cultured chick embryo hepatocytes. Dose-response effects for the induction of total cytochrome P450 ethoxyresorufin-O-deethylase (EROD) activity, and benzphetamine demethylase (BPDM) activity were studied using 10 selected tetra- to hexachlorinated PCB congeners. These studies revealed that PCBs caused effects in the chick hepatocyte culture different from previously observed effects in rat liver. Based on their effects in chick hepatocytes, the PCBs could be categorized into two groups. The first group (consisting of 3,3',4,4'-PCB, 3,3',4,4',5-PCB, 3,3',4,4',5,5'-PCB, 2',3,3',4,5-PCB, 2,3,3',4,4',5'-PCB, and 2,3,4,4',5-PCB) induced total cytochrome P450 2.4- to 2.9-fold and EROD activity from 1-2 pmol/min/mg protein to 162-247. There was marked variation in potency, but all these congeners had a maximal inducing dose above which cytochrome P450 concentrations and EROD activities declined. BPDM activities were increased only slightly (1.2- to 1.6-fold) at the maximal cytochrome P450 inducing dose. The second group of congeners (consisting of 2,2',4,5,5'-PCB. 2,2',4,4',5,5'-PCB, an...Continue Reading
References
May 1, 1978·Toxicology and Applied Pharmacology·R W MooreS D Aust
Nov 1, 1977·Clinical Pharmacology and Therapeutics·A P Alvares, A Kappas
Apr 19, 1978·Biochimica Et Biophysica Acta·S KawanishiS Sano
Feb 14, 1979·Biochemical and Biophysical Research Communications·J F SinclairH L Bonkowsky
Feb 1, 1989·Archives of Biochemistry and Biophysics·D R DuttonA Parkinson
Apr 15, 1989·Biochemical Pharmacology·M PüttmannL Robertson
Feb 1, 1989·Archives of Biochemistry and Biophysics·D R Dutton, A Parkinson
Mar 15, 1988·Biochemical Pharmacology·S A SundstromP R Sinclair
Jun 20, 1988·FEBS Letters·J E Francis, A G Smith
Feb 15, 1989·The Biochemical Journal·P SinclairH Bonkovsky
Feb 15, 1989·The Biochemical Journal·J M JacobsJ A Goldstein
Jan 15, 1986·Biochemical Pharmacology·M A DenommeS Safe
Jul 1, 1986·The Biochemical Journal·P R SinclairG H Elder
Apr 1, 1986·The Biochemical Journal·S SassaA Kappas
Feb 15, 1988·The Biochemical Journal·F De MatteisR Hempenius
Dec 1, 1988·Toxicology and Applied Pharmacology·R W LambrechtJ F Sinclair
Sep 1, 1988·Journal of Biochemistry·Y HokamaH Yoshimura
Nov 15, 1987·The Biochemical Journal·S I ShedlofskyJ M Robinson
Oct 15, 1987·Biochemical Pharmacology·P L IversenE Bresnick
May 1, 1986·Toxicology·T SawyerS Safe
Mar 1, 1986·The Biochemical Journal·J F SinclairP R Sinclair
Oct 1, 1986·Archives of Toxicology·R J Topp, P J van Bladeren
Oct 15, 1985·Biochemical Pharmacology·H SchrammF Oesch
Jan 1, 1974·Archives of Toxicology·A SchmoldtR Frühling
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A P AlvaresA Kappas
Feb 1, 1974·Toxicology and Applied Pharmacology·J A GoldsteinD L Jue
Jan 1, 1984·Critical Reviews in Toxicology·S Safe
Oct 1, 1982·Chemico-biological Interactions·L W RobertsonS Safe
Feb 21, 1983·FEBS Letters·P R SinclairJ F Sinclair
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J W HamiltonS E Bloom
Jul 15, 1983·The Biochemical Journal·H De VerneuilA Kappas
Oct 1, 1983·Biochemical Pharmacology·M A DenommeS Safe
Sep 15, 1984·The Biochemical Journal·P R SinclairJ F Sinclair
Mar 1, 1980·Chemico-biological Interactions·A ParkinsonS Safe
Jun 1, 1980·Chemico-biological Interactions·A ParkinsonS Safe
Mar 24, 1980·Life Sciences·K K KohliJ D McKinney
Apr 1, 1981·Chemico-biological Interactions·A ParkinsonS Safe
Jun 29, 1981·FEBS Letters·S KawanishiS Sano
Oct 1, 1981·Biochemical Pharmacology·J F SinclairH Bonkowsky
Sep 1, 1982·Toxicology Letters·T Sawyer, S Safe
May 15, 1983·The Biochemical Journal·S I ShedlofskyJ S Pomeroy
Apr 15, 1982·The Biochemical Journal·J F SinclairH L Bonkowsky
May 22, 1980·Biochimica Et Biophysica Acta·B GrandchampY Nordmann
Aug 1, 1955·Biochimica Et Biophysica Acta·E F NEUFELDS P COLOWICK
Apr 1, 1963·The Biochemical Journal·R J PORRA, O T JONES
Citations
Jan 12, 2000·Journal of Biochemical and Molecular Toxicology·J R Petrulis, N J Bunce
May 8, 2001·Environmental Toxicology·J R PetrulisN J Bunce
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J T BorlakogluR R Dils
Mar 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A LorenzenS W Kennedy
Feb 7, 1997·Biochemical Pharmacology·A LorenzenM E Hahn
Apr 4, 1997·Biochemical Pharmacology·R D WhiteJ J Stegeman
Nov 1, 2000·Chemosphere·A S Van der BurghtM van den Berg
Feb 13, 2001·Aquatic Toxicology·J J Schlezinger, J J Stegeman
Jun 4, 1999·Toxicology Letters·J R Petrulis, N J Bunce
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R P Gupta, M B Abou-Donia
Sep 15, 2012·Environmental Science & Technology·Izabela Kania-KorwelHans-Joachim Lehmler
Mar 27, 2013·Chemical Research in Toxicology·Ian K LaiLarry W Robertson
Oct 15, 1994·European Journal of Biochemistry·E E CableH L Bonkovsky
Feb 16, 2008·PPAR Research·Larry W RobertsonHelmut Thomas
Jul 1, 1995·Environmental Science and Pollution Research International·M TysklindM van den Berg
Jan 1, 1990·Critical Reviews in Toxicology·S Safe
Nov 22, 2008·Toxicology·Xing HanA Michael Kaplan
Jul 29, 2008·Journal of Biotechnology·L MarohnR Hanel
May 15, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jing LiuYang Song
Feb 26, 1999·Toxicology and Applied Pharmacology·A S van der BurghtM van den Berg
Jul 25, 2012·Toxicology·Ian K LaiAlicia K Olivier
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S I ShedlofskyL W Robertson
Jan 1, 1994·Critical Reviews in Toxicology·S H Safe
Mar 1, 1991·Biochemical Pharmacology·L E RodmanL W Robertson
May 1, 1992·Toxicology and Applied Pharmacology·L C ChenL W Robertson
Sep 1, 1990·Archives of Biochemistry and Biophysics·P R SinclairJ F Sinclair
Oct 17, 2020·Environmental Science & Technology·Chun-Yun ZhangHans-Joachim Lehmler