Effects of polycyclic aromatic hydrocarbon exposure and miRNA variations on peripheral blood leukocyte DNA telomere length: A cross-sectional study in Henan Province, China

The Science of the Total Environment
Xiaoran DuanYongli Yang


Telomeres play a major role in human aging and disease, especially in most cancers. Telomere length was shortened in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and influenced by individual genetic variations in telomere-binding proteins. MicroRNAs (miRNAs) can affect the progress of messenger RNA (mRNA) transcription; however, whether polymorphisms in miRNA can act on the telomere length is still unknown. Therefore, we aimed to explore the relationships between telomere damage and genetic polymorphisms in miRNA or environmental exposure. A total of 544 coke oven workers and 238 healthy controls were recruited. After collecting peripheral blood and extracting the genomic DNA of the study subjects, the telomere length (TL) in their leucocytes was detected by a real-time quantitative polymerase chain reaction (PCR), and polymorphisms in miRNAs were genotyped using the flight mass spectrometry technique. The concentrations of the four urine OH-PAHs were determined by high performance liquid chromatography (HPLC), and the Soxhlet extraction method was used to detect the concentration of coke oven emissions (COEs) in the air. We found that the peripheral blood leucocyte DNA TL was significantly shorter in the exposure...Continue Reading


May 31, 2001·Nature Genetics·K L RudolphR A DePinho
Dec 12, 2002·EMBO Reports·Daniela RhodesLynda Chapman
Nov 5, 2003·Environmental Health Perspectives·Berrin SerdarStephen M Rappaport
Feb 27, 2004·Occupational and Environmental Medicine·E SiwińskaL Kapka
Dec 26, 2009·Biochemical and Biophysical Research Communications·Yanqin SunLinlang Guo
Dec 1, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun ShenFeng Jiang
May 20, 2011·Trends in Genetics : TIG·Myriam Gorospe, Kotb Abdelmohsen
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Riccardo CazzoliHarvey I Pass
Feb 4, 2014·Cell Death and Differentiation·M E FioriR De Maria
Jun 6, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Youngsoo LeePeter J McKinnon
Nov 19, 2015·BMC Medical Genetics·Diego Chacon-CortesLyn R Griffiths
Jun 2, 2016·Journal of the National Cancer Institute·Eric PolleyBeverly A Teicher
Oct 22, 2016·Medical & Biological Engineering & Computing·Xiaoran DuanYongjun Wu
Mar 31, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiang YangLongbang Chen
Jul 7, 2018·Environmental Pollution·Almudena Espín-PérezTheo M C M de Kok
Oct 30, 2018·Nucleic Acids Research·Tingting DengZhou Songyang
Jan 2, 2019·Ecotoxicology and Environmental Safety·Xiaomin HuangYankai Xia
Jan 27, 2019·Ecotoxicology and Environmental Safety·Wei WangYongli Yang
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yingjuan LuJinsong Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.