Effects of polycystic ovarian syndrome on in vitro fertilization-embryo transfer outcomes are influenced by body mass index

Fertility and Sterility
Betsy McCormickMira Aubuchon

Abstract

To determine whether polycystic ovary syndrome (PCOS) adversely impacts IVF-embryo transfer outcomes in obese compared to lean patients. Retrospective chart review. University-affiliated infertility program. Lean non-PCOS (n = 52), lean PCOS (n = 6), obese non-PCOS (n = 18), and obese PCOS (n = 10). Ninety-four fresh nondonor IVF-embryo transfer cycles analyzed. Cycle characteristics, clinical pregnancy (PR) and live birth rates. Lean PCOS had more dominant follicles (12.2 +/- 6.0 vs. 7.7 +/- 3.6), retrieved oocytes (22.2 +/- 9.2 vs. 12.6 +/- 5.8), and frozen embryos (5 +/- 4.6 vs. 1.4 +/- 2.6) than lean non-PCOS. Lean PCOS also used fewer gonadotropin ampules (18.8 +/- 6.0 vs. 29.2 +/- 14.2), but had more retrieved oocytes (22.2 +/- 9.2 vs.14.3 +/- 4.9) than obese PCOS. Obese non-PCOS had better-grade embryos (2.1 +/- 0.8 vs. 2.7 +/- 0.8) and fewer embryos transferred (2.4 +/- 0.6 vs. 2.9 +/- 0.6) than obese PCOS, but more embryos frozen than lean non-PCOS (3.2 +/- 3.2 vs. 1.4 +/- 2.6). Implantation rates trended downward in obese patients with PCOS, but no other differences were observed. Patients with PCOS with a body mass index (BMI) in the lean rather than the obese range have more favorable assisted reproductive technolog...Continue Reading

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Citations

Mar 8, 2012·Reproduction, Fertility, and Development·Linda L-Y WuRebecca L Robker
Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher J Brewer, Adam H Balen
Aug 26, 2009·Women's Health·Angelica Lindén Hirschberg
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Jan 5, 2013·Gynécologie, obstétrique & fertilité·N SermondadeC Sifer
May 16, 2012·Fertility and Sterility·Vasiliki A MoragianniDavid A Ryley
Nov 6, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tawiwan Pantasri, Robert John Norman
Mar 25, 2014·American Journal of Obstetrics and Gynecology·Amelia P BaileyElena H Yanushpolsky
Mar 10, 2015·Reproduction, Fertility, and Development·Tawiwan PantasriRebecca L Robker
Mar 3, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dan ZhangXiue Lu
Sep 28, 2017·Journal of Assisted Reproduction and Genetics·José BellverUNKNOWN Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF)
Apr 20, 2018·Frontiers in Endocrinology·Konstantinos Tziomalos, Konstantinos Dinas
Jan 19, 2021·Zygote : the Biology of Gametes and Early Embryos·Stanly KamardiJaqueline Sudiman
Jan 15, 2010·Current Opinion in Obstetrics & Gynecology

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