PMID: 9638532Jun 25, 1998Paper

Effects of polyelectrolyte complex (PEC) on human periodontal ligament fibroblast (HPLF) function. II. Enhancement of HPLF differentiation and aggregation on PEC by L-ascorbic acid and dexamethasone

Journal of Biomedical Materials Research
T HamanoK Abe

Abstract

In addition to many types of extra cellular matrix (ECM) in vivo, cells are stimulated by many types of vitamins, hormones, growth factors, etc. In this paper the effects of L-ascorbic acid 2-phosphate (Asc-2P) and dexamethasone (Dex) on proliferation and differentiation of human periodontal ligament fibroblast (HPLF) using polyelectrolyte complex (PEC) as a matrix in vitro will be discussed. The PEC was composed of chitosan as a polycation, with carboxymethyl (CPEC) or sulfated chitin (SPEC). Asc-2P (0.2 mM) inhibited the growth of HPLF on CPEC, but promoted the growth on SPEC. Moreover, the aggregation of HPLF on CPEC was inhibited by Asc-2P, but that on SPEC was induced in the presence of Asc-2P and Dex. Although Asc-2P reduced an increase in alkaline phosphatase (ALPase) activity of HPLF on CPEC as well, it induced a twofold increase in ALPase activities on SPEC and TCD. Furthermore, in the medium containing Asc-2P and 100 mM of Dex, cell growth was inhibited, but ALPase activity was promoted on both SPEC and TCD to form many aggregates on SPEC. ALPase activity increased by twofold over that of HPLF cultured in the medium containing only Asc-2P. Therefore, it is suggested that the cell functions of HPLF are controlled by th...Continue Reading

References

May 1, 1992·Calcified Tissue International·M I ChoP R Ramakrishnan
Apr 1, 1992·Journal of Biomedical Materials Research·T L BonfieldJ M Anderson
Dec 1, 1986·Calcified Tissue International·K H Wlodarski, A H Reddi
Sep 1, 1988·The Journal of Nihon University School of Dentistry·M OhshimaK Suzuki
Nov 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J C Bowersox, N Sorgente
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S MuradS R Pinnell
Nov 1, 1983·The Journal of Cell Biology·A S CurtisF Lawrie
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D M Peehl, E J Stanbridge
May 1, 1995·In Vitro Cellular & Developmental Biology. Animal·T GolombickW R Bezwoda
Jun 1, 1995·Calcified Tissue International·R M NohutcuL K McCauley
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J Y WongD E Ingber
Mar 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S E HarrisG R Mundy
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·K L CrossinG M Edelman

❮ Previous
Next ❯

Citations

Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J BergerR Gurny
Oct 17, 2014·Experimental Lung Research·Lu-Lu ZhouXue-Yin Shi
Apr 12, 2002·Journal of Biomedical Materials Research·Petra Tryoen-TóthJoëlle Ogier
May 21, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Huifang ZhouXianqun Fan
Feb 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Quan-Li LiGuo-Min Ou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinics in Podiatric Medicine and Surgery
Jerome K Steck
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
H LiS Kadota
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
G KratzO Larm
© 2022 Meta ULC. All rights reserved