Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

Nutrients
Rosanna MatteraRoberto Bei

Abstract

Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes. Polyphenols are a large group of natural compounds ubiquitously expressed in plants, and epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of various ROS-mediated human diseases. Polyphenols reduce cardiomyocytes damage, necrosis, apoptosis, infarct size and improve cardiac function by decreasing oxidative stress-induced production of ROS or RNS. These effects are achieved by the ability of polyphenols to modulate the expression and activity of anti-oxidant enzymes and several signaling pathways involved in cells survival. This report reviews current knowledge on the pot...Continue Reading

References

Jan 19, 1999·Cardiology Clinics·A M Ball, M J Sole
Jun 29, 2000·Journal of Hypertension·N S DhallaT Netticadan
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Zuo-Hui ShaoChun-Su Yuan
Jan 29, 2003·The Journal of Nutritional Biochemistry·Kellie L. Tuck, Peter J. Hayball
Nov 1, 2003·Antioxidants & Redox Signaling·Abdelkarim SabriPamela A Lucchesi
Apr 29, 2004·The American Journal of Clinical Nutrition·Claudine ManachLiliana Jiménez
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul A TownsendAnastasis Stephanou
Jan 11, 2005·The American Journal of Clinical Nutrition·Claudine ManachChristian Rémésy
Jul 29, 2005·Critical Reviews in Food Science and Nutrition·Augustin ScalbertLiliana Jiménez
Dec 28, 2006·Hypertension·Eiki Takimoto, David A Kass
Jan 16, 2007·Journal of Molecular and Cellular Cardiology·Ioanna AndreadouDimitrios Th Kremastinos
May 4, 2007·European Journal of Pharmacology·Wei-Tien ChangChun-Su Yuan
Aug 30, 2007·Cellular and Molecular Life Sciences : CMLS·D E Stevenson, R D Hurst
Sep 18, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L WuL Li
Oct 5, 2007·Ageing Research Reviews·Mark P Mattson
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ling LiXun Hu
Dec 25, 2007·European Journal of Pharmacology·Xiuzhen HanHongxiang Lou
Jan 8, 2008·American Journal of Physiology. Heart and Circulatory Physiology·C AngeloniS Hrelia
Feb 21, 2008·Archives of Biochemistry and Biophysics·Barry Halliwell
Mar 12, 2008·British Journal of Pharmacology·X-Y ZhaoB-F Yang
Mar 28, 2008·Experimental Biology and Medicine·Henryk DregerVerena Stangl
May 20, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nagla A El-ShitanyKarema El-desoky
Jul 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiuzhen HanHongxiang Lou
Dec 9, 2008·Biochemical and Biophysical Research Communications·Chun-Juan ChenWei Wang
Mar 18, 2009·Circulation·Vernon W DolinskyJason R B Dyck
Mar 24, 2009·Free Radical Biology & Medicine·Elizabeth D Brookins DanzRebecca S Keller
Apr 24, 2009·Journal of Cellular Biochemistry·Zuo-Hui ShaoTerry L Vanden Hoek
Sep 30, 2009·Circulation·Rossella MenghiniMassimo Federici
Nov 26, 2009·Journal of Cardiovascular Pharmacology·Bum-Yong KangJawahar L Mehta
Dec 23, 2009·Cancer Biotherapy & Radiopharmaceuticals·Jingxuan WangFeng Qi
Dec 29, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohammad Ali Esmaeili, Ali Sonboli
May 18, 2010·Cardiovascular Toxicology·Haiying Wei, Ziqiang Meng
May 27, 2010·The American Journal of Chinese Medicine·Jing LiZuo-Hui Shao
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler

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Citations

Feb 1, 2018·American Journal of Physiology. Renal Physiology·Ying SongLangchong He
Nov 15, 2018·Redox Report : Communications in Free Radical Research·Hyun-Yong KimChul-Ho Lee
Jan 12, 2019·Archives of Physiology and Biochemistry·Jovana BradicMarina Tomovic
Apr 2, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marwa G A HegazyNesma M Helal
Jul 4, 2019·Journal of Animal Physiology and Animal Nutrition·Xiaojiao XuJunqiu Luo
Feb 27, 2020·Journal of Receptor and Signal Transduction Research·Guang YangJiankun Xing
Apr 24, 2018·Oxidative Medicine and Cellular Longevity·Dong Kwon Yang, Shang-Jin Kim
Dec 26, 2018·Expert Opinion on Drug Metabolism & Toxicology·Liping WangZhongqiu Liu
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jie WangMinhui Li
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga PechanovaMartina Cebova
Jun 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ShiGuozhen Cui
Aug 17, 2018·Nutrients·Giuseppe Grosso
Apr 10, 2019·International Journal of Molecular Sciences·Chiara FocaccettiRoberto Bei
Jan 31, 2020·Oxidative Medicine and Cellular Longevity·Klara KomiciGraziamaria Corbi
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina Cebova, Olga Pechanova
Dec 24, 2018·International Journal of Molecular Sciences·Vladimir JakovljevicVesna Vucic
Sep 16, 2020·International Journal of Molecular Sciences·Monica BenvenutoRoberto Bei
Mar 14, 2019·Oxidative Medicine and Cellular Longevity·Jovana BradicMarina Tomovic
Jan 8, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ezgi GerçekÖkkeş Yılmaz
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Xuan Mei, Ke Cheng
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amir M Al HroobAyman M Mahmoud
Apr 4, 2021·Antioxidants·Katarzyna Dziąbowska-GrabiasKrzysztof Sztanke
Jul 31, 2021·Molecular and Cellular Biochemistry·Isidora MilosavljevicNebojsa Andjelkovic

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Methods Mentioned

BETA
acetylation

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